Evidence map›Paper›PMID 23410969›Full record

ArticleCancer cell2013

Growth factor receptors define cancer hierarchies.

Monica Venere, Justin D Lathia, Jeremy N Rich

Open access · bronzeAbstract readComment
In one paragraph

Article in Cancer cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Monica VenereDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Justin D Lathia
Jeremy N Rich
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · US

Funding

Targeting Brain Tumor Stem Cells Through Novel Therapeutic CombinationsR01CA154130 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI RICH, JEREMY N · 2010 to 2014
$1.9M
Stem Cell-Like Glioma Cells in AngiogenesisR01CA129958 · NCI · DUKE UNIVERSITY · PI RICH, JEREMY N · 2008 to 2012
$1.6M
Microenvironmental regulation of the cancer stem cell phenotype by integrin a6R00CA157948 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI LATHIA, JUSTIN D. · 2012 to 2014
$725k
NCI NIH HHS R00 CA157948NCI NIH HHS R01 CA129958NCI NIH HHS R01 CA154130
6 · The paper itself

Abstract

Normal and neoplastic tissues display cellular hierarchies that integrate extracellular cues to maintain tissue function through bidirectional signals mediated via cell surface proteins. Two papers in Cancer Cell, one in this issue (Day and colleagues) and one in a recent issue (Binda and colleagues), describe how Eph receptor tyrosine kinases critically define and regulate the growth of cancer stem cells.

Identifiers

PMID23410969
PMCPMC3616317
OpenAlexW1980000654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.