ArticleJournal of the International Neuropsychological Society : JINS2013
Can risk-taking be an endophenotype for bipolar disorder? A study on patients with bipolar disorder type I and their first-degree relatives.
Article in Journal of the International Neuropsychological Society : JINS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Emotion dysregulation in bipolar disorder compared to other mental illnesses: a systematic review and meta-analysis.Psychological medicine · 2023Pooled it
- Using Natural Language Processing Methods to Build the Hypersexuality in Bipolar Reddit Corpus: Infodemiology Study of Reddit.JMIR infodemiology · 2025Article
- Impulsivity, decision-making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families.Brain and behavior · 2023Article
- Does Mood Affect Judgment: Results from an In Vivo Observational Study.Current psychology (New Brunswick, N.J.) · 2023Article
- Polygenic contributions to performance on the Balloon Analogue Risk Task.Molecular psychiatry · 2023Article
- Response Inhibition and Interference Control in Adult Attention Deficit Hyperactivity Disorder.Noro psikiyatri arsivi · 2023Article
- Impulsivity in Bipolar Disorder: State or Trait?Brain sciences · 2022Review
- Impulsivity and sleep and circadian rhythm disturbance predict next-day mood symptoms in a sample at high risk for or with recent-onset bipolar spectrum disorder: An ecological momentary assessment study.Journal of affective disorders · 2022Article
- Mathematical modeling of risk-taking in bipolar disorder: Evidence of reduced behavioral consistency, with altered loss aversion specific to those with history of substance use disorder.Computational psychiatry (Cambridge, Mass.) · 2022Article
- The Effects of Citalopram and Thalamic Dopamine DPsychiatry journal · 2022Article
- Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking.Translational psychiatry · 2021Article
- Investigation of genetic loci shared between bipolar disorder and risk-taking propensity: potential implications for pharmacological interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021Review
- Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis.Frontiers in psychiatry · 2021Article
- Risky decision-making following prefrontal D1 receptor manipulation.Translational neuroscience · 2021Article
- Neurophysiological correlates of cognitive control and approach motivation abnormalities in adolescent bipolar disorders.Cognitive, affective & behavioral neuroscience · 2019Article
- ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior.Journal of neuroinflammation · 2018Article
- Integrative Understanding of Familial Impulsivity, Early Adversity and Suicide Risk.Frontiers in psychology · 2017Article
- Neurobiology of Risk for Bipolar Disorder.Current treatment options in psychiatry · 2016Review
- Lived experience at the core: A classification system for risk-taking behaviours in bipolar.Digital healthArticle
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Authors and funding
7 authors.
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Abstract
Risk-taking behavior and impulsivity are core features of bipolar disorder. Whether they are part of the inherited aspect of the illness is not clear. We aimed to evaluate risk-taking behavior as a potential endophenotype for bipolar disorders, and its relationship with impulsivity and illness features. The Balloon Analogue Risk Task (BART) and Barratt Impulsiveness Scale-11 (BIS-11) were used to assess risk-taking behavior and impulsivity respectively in 30 euthymic bipolar I patients (BD), their 25 asymptomatic first-degree relatives (BD-R), and 30 healthy controls (HC). The primary BART outcome measure was the behavioral adjustment score (number of pumps after trials where the balloon did not pop minus the number of pumps after trials where the balloon popped). BD (p < .001) and BD-R (p = .001) had similar and significantly lower adjustment scores than HC. Only BD scored significantly higher on BIS-11 total (p = .01) and motor (p = .04) subscales than HC. Neither the BART, nor impulsivity scores associated with illness features. A limitation of this study is medicated patients and a heterogeneous BD-R were included. Riskiness may be a candidate endophenotype for bipolar disorder as it appears independently from illness features, presents similarly in BD and BD-R groups and differs from impulsivity.
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