Evidence map›Paper›PMID 23410836›Full record

ArticleGenetics2013

Higher levels of neanderthal ancestry in East Asians than in Europeans.

Jeffrey D Wall, Melinda A Yang, Flora Jay, Sung K Kim, Eric Y Durand, Laurie S Stevison, Christopher Gignoux, August Woerner, Michael F Hammer, Montgomery Slatkin

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 1 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 1 synthesis or guideline pooled it, 260 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
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  6. Review
  7. G-quadruplex propensity inNAR genomics and bioinformatics · 2024
    Article
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  19. Profile of Svante Pääbo: 2022 Nobel laureate in physiology or medicine.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jeffrey D WallInstitute for Human Genetics, University of California, San Francisco, California 94143, USA. wallj@humgen.ucsf.edu
Melinda A Yang
Flora Jay
Sung K Kim
Eric Y Durand
Laurie S Stevison
Christopher Gignoux
August Woerner
Michael F Hammer
Montgomery Slatkin
University of California, Berkeley · USUniversity of California, San Francisco · USUniversity of Arizona · US

Funding

GENOMICST32HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN, Daniel Soleyman Rokhsar · 2000 to 2026
$13.5M
MODELS OF COMPLEX GENETIC SYSTEMSR01GM040282 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SLATKIN, MONTGOMERY WILSON · 1988 to 2017
$4.4M
Genomic Patterns of Polymorphism in PrimatesR01HG005226 · NHGRI · UNIVERSITY OF ARIZONA · PI HAMMER, MICHAEL F, WALL, JEFFREY D · 2010 to 2012
$1.7M
NHGRI NIH HHS R01 HG005226NHGRI NIH HHS R01-HG005226NHGRI NIH HHS T32 HG000047NHGRI NIH HHS T32 HG 00047NIGMS NIH HHS R01 GM040282NIGMS NIH HHS R01-GM40282
6 · The paper itself

Abstract

Neanderthals were a group of archaic hominins that occupied most of Europe and parts of Western Asia from ∼30,000 to 300,000 years ago (KYA). They coexisted with modern humans during part of this time. Previous genetic analyses that compared a draft sequence of the Neanderthal genome with genomes of several modern humans concluded that Neanderthals made a small (1-4%) contribution to the gene pools of all non-African populations. This observation was consistent with a single episode of admixture from Neanderthals into the ancestors of all non-Africans when the two groups coexisted in the Middle East 50-80 KYA. We examined the relationship between Neanderthals and modern humans in greater detail by applying two complementary methods to the published draft Neanderthal genome and an expanded set of high-coverage modern human genome sequences. We find that, consistent with the recent finding of Meyer et al. (2012), Neanderthals contributed more DNA to modern East Asians than to modern Europeans. Furthermore we find that the Maasai of East Africa have a small but significant fraction of Neanderthal DNA. Because our analysis is of several genomic samples from each modern human population considered, we are able to document the extent of variation in Neanderthal ancestry within and among populations. Our results combined with those previously published show that a more complex model of admixture between Neanderthals and modern humans is necessary to account for the different levels of Neanderthal ancestry among human populations. In particular, at least some Neanderthal-modern human admixture must postdate the separation of the ancestors of modern European and modern East Asian populations.

Indexed as

PhylogenyAnimalsAsia, EasternAsian PeopleGene PoolGenetics, PopulationGenome, HumanHaplotypesHumansModels, GeneticNeanderthalsWhite People

Identifiers

PMID23410836
PMCPMC3632468
OpenAlexW2127362327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.