ArticleGenetics2013
Nonrandom distribution of interhomolog recombination events induced by breakage of a dicentric chromosome in Saccharomyces cerevisiae.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Towards a unified model of aneuploid karyotype dynamics.PLoS genetics · 2026Article
- The Role of Transient Crosslinks in the Chromatin Search Response to DNA Damage.International journal of molecular sciences · 2025Article
- Centromeres are stress-induced fragile sites.Current biology : CB · 2025Article
- Dicentric chromosomes are resolved through breakage and repair at their centromeres.Chromosoma · 2024Article
- Splitting the yeast centromere by recombination.Nucleic acids research · 2024Article
- Context-dependent neocentromere activity in synthetic yeast chromosomeCell genomics · 2023Article
- Article
- Behavior of dicentric chromosomes in budding yeast.PLoS genetics · 2021Article
- Mechanisms underlying genome instability mediated by formation of foldback inversions ineLife · 2020Article
- Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal InstabilityCancers · 2018Article
- Telomere Length Dynamics and the Evolution of Cancer Genome Architecture.International journal of molecular sciences · 2018Review
- Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation.Scientific reports · 2017Article
- Ontogeny of Unstable Chromosomes Generated by Telomere Error in Budding Yeast.PLoS genetics · 2016Article
- A Cohesin-Based Partitioning Mechanism Revealed upon Transcriptional Inactivation of Centromere.PLoS genetics · 2016Article
- Preferential Breakpoints in the Recovery of Broken Dicentric Chromosomes in Drosophila melanogaster.Genetics · 2015Article
- Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions.Genes & development · 2015Article
- Polymer models of interphase chromosomes.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Dicentric chromosomes undergo breakage in mitosis, resulting in chromosome deletions, duplications, and translocations. In this study, we map chromosome break sites of dicentrics in Saccharomyces cerevisiae by a mitotic recombination assay. The assay uses a diploid strain in which one homolog has a conditional centromere in addition to a wild-type centromere, and the other homolog has only the wild-type centromere; the conditional centromere is inactive when cells are grown in galactose and is activated when the cells are switched to glucose. In addition, the two homologs are distinguishable by multiple single-nucleotide polymorphisms (SNPs). Under conditions in which the conditional centromere is activated, the functionally dicentric chromosome undergoes double-stranded DNA breaks (DSBs) that can be repaired by mitotic recombination with the homolog. Such recombination events often lead to loss of heterozygosity (LOH) of SNPs that are centromere distal to the crossover. Using a PCR-based assay, we determined the position of LOH in multiple independent recombination events to a resolution of ∼4 kb. This analysis shows that dicentric chromosomes have recombination breakpoints that are broadly distributed between the two centromeres, although there is a clustering of breakpoints within 10 kb of the conditional centromere.
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