ArticleGenetics2013
Fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Why recombination hotspots?PLoS genetics · 2026Review
- Fine-scale contemporary recombination variation and its fitness consequences in adaptively diverging stickleback fish.Nature ecology & evolution · 2024Article
- Variation in fine-scale recombination rate in temperature-evolved Drosophila melanogaster populations in response to selection.G3 (Bethesda, Md.) · 2022Article
- The Theory and Applications of Measuring Broad-Range and Chromosome-Wide Recombination Rate from Allele Frequency Decay around a Selected Locus.Molecular biology and evolution · 2020Article
- Predicting the Landscape of Recombination Using Deep Learning.Molecular biology and evolution · 2020Article
- DNA Motifs Are Not General Predictors of Recombination in Two Drosophila Sister Species.Genome biology and evolution · 2019Article
- Pervasive gene conversion in chromosomal inversion heterozygotes.Molecular ecology · 2019Article
- Female Meiosis: Synapsis, Recombination, and Segregation inGenetics · 2018Review
- Background selection as null hypothesis in population genomics: insights and challenges fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Predictive Models of Recombination Rate Variation across the Drosophila melanogaster Genome.Genome biology and evolution · 2016Article
- Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females.G3 (Bethesda, Md.) · 2016Article
- Article
- The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster.PLoS genetics · 2016Article
- Bias-Variance Tradeoffs in Recombination Rate Estimation.Genetics · 2016Article
- A Comment on Fine-Scale Heterogeneity in Crossover Rate in the garnet-scalloped Region of the Drosophila melanogaster X Chromosome.Genetics · 2015Article
- Recombining without Hotspots: A Comprehensive Evolutionary Portrait of Recombination in Two Closely Related Species of Drosophila.Genome biology and evolution · 2015Article
- Multi-locus analysis of genomic time series data from experimental evolution.PLoS genetics · 2015Article
- Background selection as baseline for nucleotide variation across the Drosophila genome.PLoS genetics · 2014Article
- High-resolution linkage map for two honeybee chromosomes: the hotspot quest.Molecular genetics and genomics : MGG · 2014Article
- Article
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4 authors.
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Abstract
Homologous recombination affects myriad aspects of genome evolution, from standing levels of nucleotide diversity to the efficacy of natural selection. Rates of crossing over show marked variability at all scales surveyed, including species-, population-, and individual-level differences. Even within genomes, crossovers are nonrandomly distributed in a wide diversity of taxa. Although intra- and intergenomic heterogeneities in crossover distribution have been documented in Drosophila, the scale and degree of crossover rate heterogeneity remain unclear. In addition, the genetic features mediating this heterogeneity are unknown. Here we quantify fine-scale heterogeneity in crossover distribution in a 2.1-Mb region of the Drosophila melanogaster X chromosome by localizing crossover breakpoints in 2500 individuals, each containing a single crossover in this specific X chromosome region. We show 90-fold variation in rates of crossing over at a 5-kb scale, place this variation in the context of several aspects of genome evolution, and identify several genetic features associated with crossover rates. Our results shed new light on the scale and magnitude of crossover rate heterogeneity in D. melanogaster and highlight potential features mediating this heterogeneity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.