ArticleBiochemical and biophysical research communications2013
Oxytocin modulates mTORC1 pathway in the gut.
Article in Biochemical and biophysical research communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids.European journal of histochemistry : EJH · 2014Trial
- OXTR-mediated signaling in astrocytes contributes to anxiolysis.Molecular psychiatry · 2025Article
- The intertwining of oxytocin's effects on social affiliation and inflammation.Comprehensive psychoneuroendocrinology · 2024Article
- Breast milk oxytocin and s-IgA modulate infant biomarkers and social engagement; The role of maternal anxiety.Comprehensive psychoneuroendocrinology · 2024Article
- Fantastic voyage:Comprehensive psychoneuroendocrinology · 2024Review
- Does activation of oxytocinergic reward circuits postpone the decline of the aging brain?Frontiers in psychology · 2023Review
- Oxytocin and oxygen: the evolution of a solution to the 'stress of life'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- High Oxytocin Receptor Expression Linked to Increased Cell Migration and Reduced Survival in Patients with Triple-Negative Breast Cancer.Biomedicines · 2022Article
- Oxytocin and secretin receptors - implications for dry eye syndrome and ocular pain.Frontiers in ophthalmology · 2022Review
- TRPV1, Nrf2, and COVID-19: Could Oxytocin Have a Beneficial Role to Play?International archives of allergy and immunology · 2022Article
- Bacillus Calmette-Guérin in Immuno-Regulation of Alzheimer's Disease.Frontiers in aging neuroscience · 2022Review
- Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020Review
- Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response.Neurotoxicity research · 2019Review
- Oxytocin Inhibition of Metastatic Colorectal Cancer by Suppressing the Expression of Fibroblast Activation Protein-α.Frontiers in neuroscience · 2019Article
- Human adipose tissue protein analyses using capillary western blot technology.Nutrition & diabetes · 2018Article
- In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.International journal of molecular medicine · 2016Article
- Capillary nano-immunoassays: advancing quantitative proteomics analysis, biomarker assessment, and molecular diagnostics.Journal of translational medicine · 2015Review
- Oxytocin modulates markers of the unfolded protein response in Caco2BB gut cells.Cell stress & chaperones · 2014Article
- Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors.Annals of surgical oncology · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Our recent findings of a weaning-related pattern of oxytocin (OT) and OT receptor (OTR) expression in the rat enteric nervous system and in villus-crypt enterocytes, together with the known high level and stability of OT in breast milk support that OT may play a role in gut function and development. We previously described a biphasic dose-response of the PI3K/Akt pathway in gut cells treated with OT. Activation peaked at 62.5 nM OT (30 min) and coincided with OTR internalization. Here we use automated Western blotting to further explore OT-elicited changes in Akt and pAkt(T308), as well as in downstream substrates p70 S6 kinase-1 (S6K1) and eIF-4E binding protein 1 (4E-BP1). Relative to fresh growth medium (FGM) alone, our results showed OT in FGM reduced the abundance and phosphorylation of S6K1 and the phosphorylation of 4E-BP1, both substrates of mammalian target of rapamycin complex 1 (mTORC1). Phosphorylation of mTORC1 regulator, Raptor(S792), was increased by high and low OT concentrations, with predicted inhibitory effects on mTORC1. OT thus downregulates anabolic effects induced by FGM activity catalyzed by mTORC1. OT is a regulator of the PI3K/Akt/mTORC1 pathway in Caco2BB cells and may modulate translation in gut cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.