ArticlePsychological medicine2013
Schizophrenia genetic variants are not associated with intelligence.
Article in Psychological medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study.Molecular psychiatry · 2021Pooled it
- Heritability of Neuropsychological Measures in Schizophrenia and Nonpsychiatric Populations: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2017Pooled it
- Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).Molecular psychiatry · 2014Pooled it
- A review of the cognitive impact of neurodevelopmental and neuropsychiatric associated copy number variants.Translational psychiatry · 2023Review
- The contribution of copy number variants to psychiatric symptoms and cognitive ability.Molecular psychiatry · 2023Review
- The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia.Schizophrenia bulletin · 2020Article
- Genetic Overlap between General Cognitive Function and Schizophrenia: A Review of Cognitive GWASs.International journal of molecular sciences · 2018Review
- Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia.Schizophrenia research. Cognition · 2018Article
- The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project.Schizophrenia research · 2018Article
- Association of Childhood Infection With IQ and Adult Nonaffective Psychosis in Swedish Men: A Population-Based Longitudinal Cohort and Co-relative Study.JAMA psychiatry · 2018Article
- A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Review
- A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Is the association between offspring intelligence and parents' educational attainment influenced by schizophrenia or mood disorder in parents?Schizophrenia research. Cognition · 2017Article
- Evidence of Common Genetic Overlap Between Schizophrenia and Cognition.Schizophrenia bulletin · 2016Article
- The association between family history of mental disorders and general cognitive ability.Translational psychiatry · 2014Article
- Polygenic risk scores for smoking: predictors for alcohol and cannabis use?Addiction (Abingdon, England) · 2014Article
- Polygenic determinants of white matter volume derived from GWAS lack reproducibility in a replicate sample.Translational psychiatry · 2014Article
- Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins.Translational psychiatry · 2014Article
- Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.Genome medicine · 2014Review
- Integrating genetics and social science: genetic risk scores.Biodemography and social biology · 2014Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundSchizophrenia is associated with lower pre-morbid intelligence (IQ) in addition to (pre-morbid) cognitive decline. Both schizophrenia and IQ are highly heritable traits. Therefore, we hypothesized that genetic variants associated with schizophrenia, including copy number variants (CNVs) and a polygenic schizophrenia (risk) score (PSS), may influence intelligence.
methodIQ was estimated with the Wechsler Adult Intelligence Scale (WAIS). CNVs were determined from single nucleotide polymorphism (SNP) data using the QuantiSNP and PennCNV algorithms. For the PSS, odds ratios for genome-wide SNP data were calculated in a sample collected by the Psychiatric Genome-Wide Association Study (GWAS) Consortium (8690 schizophrenia patients and 11 831 controls). These were used to calculate individual PSSs in our independent sample of 350 schizophrenia patients and 322 healthy controls.
resultsAlthough significantly more genes were disrupted by deletions in schizophrenia patients compared to controls (p = 0.009), there was no effect of CNV measures on IQ. The PSS was associated with disease status (R 2 = 0.055, p = 2.1 × 10-7) and with IQ in the entire sample (R 2 = 0.018, p = 0.0008) but the effect on IQ disappeared after correction for disease status.
conclusionsOur data suggest that rare and common schizophrenia-associated variants do not explain the variation in IQ in healthy subjects or in schizophrenia patients. Thus, reductions in IQ in schizophrenia patients may be secondary to other processes related to schizophrenia risk.
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