Trial reportJournal of the American College of Cardiology2013
Prognostic impact of the presence and absence of angina on mortality and cardiovascular outcomes in patients with type 2 diabetes and stable coronary artery disease: results from the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial.
Trial report in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00006305 (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease.The Cochrane database of systematic reviews · 2018Pooled it
- Intentional coronary revascularization versus conservative therapy in patients after peripheral artery revascularization due to critical limb ischemia: the INCORPORATE trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Trial
- Mortality implications of angina and blood pressure in hypertensive patients with coronary artery disease: New data from extended follow-up of the International Verapamil/Trandolapril Study (INVEST).Clinical cardiology · 2013Trial
- Myocardial Ischaemic Syndromes: Shifting from a Coronary-centric to a Substrate-based Nomenclature is More Accurate and Inclusive.European cardiology · 2025Review
- Machine Learning-Driven Metabolic Syndrome Prediction: An International Cohort Validation Study.Healthcare (Basel, Switzerland) · 2024Article
- Development and validation of nomograms for predicting cardiovascular disease risk in patients with prediabetes and diabetes.Scientific reports · 2024Article
- Medium-Term Impact of the Coronavirus Disease 2019 Pandemic on the Practice of Percutaneous Coronary Interventions in Japan.Journal of atherosclerosis and thrombosis · 2022Article
- Prognostic value of coronary microvascular dysfunction assessed by coronary angiography-derived index of microcirculatory resistance in diabetic patients with chronic coronary syndrome.Cardiovascular diabetology · 2022Article
- International Observational Analysis of Evolution and Outcomes of Chronic Stable Angina: The Multinational CLARIFY Study.Circulation · 2021Article
- Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women's Ischemic Syndrome Evaluation study (WISE).International journal of cardiology. Heart & vasculature · 2020Article
- Angina Severity, Mortality, and Healthcare Utilization Among Veterans With Stable Angina.Journal of the American Heart Association · 2019Article
- Clinical significance of chronic myocardial ischemia in coronary artery disease patients.Journal of thoracic disease · 2019Review
- Impact of Follow-Up Ischemia on Myocardial Perfusion Single-Photon Emission Computed Tomography in Patients with Coronary Artery Disease.Yonsei medical journal · 2017Article
- Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry.Journal of the American Heart Association · 2016Article
- Determining the Most Appropriate Mode of Coronary Artery Revascularisation in Patients With Diabetes.Interventional cardiology (London, England) · 2016Article
- Does ischemia burden in stable coronary artery disease effectively identify revascularization candidates? Ischemia burden in stable coronary artery disease does not effectively identify revascularization candidates.Circulation. Cardiovascular imaging · 2015Article
- Comparison of the hospital arrival time and differences in pain quality between diabetic and non-diabetic STEMI patients.International journal of environmental research and public health · 2015Article
- Coronary artery disease and diabetes mellitus.Cardiology clinics · 2014Review
- Chronic condition comorbidity and multidrug therapy in general practice populations: a cross-sectional linkage study.BMJ open · 2014Article
- Coronary artery revascularization in patients with diabetes mellitus.Circulation · 2013Review
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Authors and funding
11 authors at 8 institutions in 3 countries.
Funding
Abstract
objectivesThe purpose of this analysis was to assess in patients with type 2 diabetes and stable coronary artery disease (CAD) whether the risk of all-cause mortality and cardiovascular events varied according to the presence or absence of angina and angina equivalent symptoms.
backgroundData on the prognostic value of symptoms in these patients are limited.
methodsPost-hoc analysis was performed in 2,364 patients with type 2 diabetes and documented CAD enrolled in the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial to determine the occurrence of death and composite of death, myocardial infarction, and stroke during a 5-year follow-up according to cardiac symptoms at baseline.
resultsThere were 1,434 patients with angina (A), 506 with angina equivalents (E), and 424 with neither of these (N). The cumulative death rates (total 316) were 12% in A, 14% in E, and 10% in N (p = 0.3), and cardiovascular composite rates (total 548) were 24% in A, 24% in E, and 21% in N (p = 0.5). Compared with N, the hazard ratios adjusted for confounders were not different for death in A (1.11; 99% CI: 0.81 to 1.53) and E (1.17; 99% CI: 0.81 to 1.68) or for cardiovascular events in A (1.17; 99% CI: 0.92 to 1.50) and E (1.11; 99% CI: 0.84 to 1.48).
conclusionsWhatever their symptom status, patients with type 2 diabetes and stable CAD were at similar risk of cardiovascular events and death. These findings suggest that these patients may be similarly managed in terms of risk stratification and preventive therapies. (Bypass Angioplasty Revascularization Investigation 2 Diabetes [BARI 2D]; NCT00006305).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.