SynthesisProgress in neuro-psychopharmacology & biological psychiatry2013
Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder.
Synthesis in Progress in neuro-psychopharmacology & biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Differences in cortical gyrification and fractional amplitude of low-frequency fluctuations between early- and late-onset obsessive-compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2026Article
- Moving beyond symptom subtypes: testing a common dimension of lifetime OCD symptoms.CNS spectrums · 2025Article
- Harm Avoidance and Incompleteness as Motivational Dimensions of OCD: Associations with Clinical and Demographic Traits.Cognitive therapy and research · 2025Article
- Clinical characteristics and treatment response of a possible self-contamination subtype of obsessive-compulsive disorder: a prospective investigation.BMC psychiatry · 2025Article
- Early Identification and Intervention in Pediatric Obsessive-Compulsive Disorder.Brain sciences · 2023Review
- SAPAP3, SPRED2, and obsessive-compulsive disorder: the search for fundamental phenotypes.Frontiers in molecular neuroscience · 2023Article
- Familial risk of psychosis in obsessive-compulsive disorder: Impact on clinical characteristics, comorbidity and treatment response.Journal of psychiatric research · 2022Article
- A multi-method examination of the link between obsessive-compulsive symptomatology and emotion-related impulsivity.The British journal of clinical psychology · 2021Article
- Symmetry Dimension in Obsessive-Compulsive Disorder: Prevalence, Severity and Clinical Correlates.Journal of clinical medicine · 2021Article
- Are There Familial Patterns of Symptom Dimensions in Obsessive-Compulsive Disorder?Frontiers in psychiatry · 2021Article
- Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders.International clinical psychopharmacology · 2020Review
- Hoarding in children and adolescents with obsessive-compulsive disorder: prevalence, clinical correlates, and cognitive behavioral therapy outcome.European child & adolescent psychiatry · 2019Article
- A Clinical Staging Model for Obsessive-Compulsive Disorder: Is It Ready for Prime Time?EClinicalMedicine · 2019Review
- Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2016Article
- Toward understanding the heterogeneity in obsessive-compulsive disorder: Evidence from narratives in adult patients.The Australian and New Zealand journal of psychiatry · 2016Article
- Three Reasons why Studying Hoarding in Children and Adolescents is Important.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2015Article
- Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Review
Corrections and comments
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8 authors.
Funding
Abstract
Meta-analysis of the heterogeneous symptoms of obsessive-compulsive disorder (OCD) has found a four-factor structure of symptom dimensions consisting of cleaning, forbidden thoughts, symmetry, and hoarding. Research into age of onset of symptom dimensions has yielded inconsistent results, and it is unknown whether symptoms along these dimensions differ in their clinical course. We assessed age of onset and clinical course of different OCD symptom dimensions in a large cohort of adult patients. Nine-hundred fifty-five subjects were assessed using the Dimensional Yale-Brown Obsessive-Compulsive Scale. For age of onset analysis, we tested across three methods of classification: (1) primary (more severe) symptom dimension (2) clinically significant symptoms within a dimension or (3) any symptoms within a dimension. Age of onset was defined as the earliest age of onset reported for any individual item within a symptom dimension. For analysis of different types of clinical course, we used chi-square tests to assess for differences between primary symptom dimensions. OCD symptoms in the symmetry dimension had an earlier age of onset than other OCD symptom dimensions. These findings remained significant across all three methods of classification and controlling for gender and comorbid tics. No significant differences were found between the other dimensions. Subjects with primary OCD symptoms in the forbidden thoughts dimension were more likely to report a waxing-and-waning course, whereas symmetry symptoms were less likely to be associated with a waxing-and-waning course.
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