ArticleMicrobial cell factories2013
Why and how protein aggregation has to be studied in vivo.
Article in Microbial cell factories, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Optimization of a High-Throughput Screen for Monitoring Disease-Associated Protein Misfolding and Aggregation in Bacteria.ACS synthetic biology · 2025Article
- Insights and Perspectives on the Role of Proteostasis and Heat Shock Proteins in Fungal Infections.Microorganisms · 2023Review
- Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein.Science advances · 2022Article
- Pathological ATX3 Expression Induces Cell Perturbations inInternational journal of molecular sciences · 2021Article
- MultidirectionalJournal of enzyme inhibition and medicinal chemistry · 2020Article
- Bifunctional ligand design for modulating mutant p53 aggregation in cancer.Chemical science · 2019Article
- GroEL/ES mediated the in vivo recovery of TRAIL inclusion bodies in Escherichia coli.Scientific reports · 2018Article
- Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction.The Journal of biological chemistry · 2018Article
- Twin arginine translocation system in secretory expression of recombinant human growth hormone.Research in pharmaceutical sciences · 2016Article
- Protein aggregation and membrane lipid modifications under lactic acid stress in wild type and OPI1 deleted Saccharomyces cerevisiae strains.Microbial cell factories · 2016Article
- Mammalian prion protein (PrP) forms conformationally different amyloid intracellular aggregates in bacteria.Microbial cell factories · 2015Article
- The prion-like RNA-processing protein HNRPDL forms inherently toxic amyloid-like inclusion bodies in bacteria.Microbial cell factories · 2015Article
- Article
- Identification and glycerol-induced correction of misfolding mutations in the X-linked mental retardation gene CASK.PloS one · 2014Article
- Recombinant polypeptide production in E. coli: towards a rational approach to improve the yields of functional proteins.Microbial cell factories · 2013Review
- Protein folding and assembly in confined environments: Implications for protein aggregation in hydrogels and tissues.Biotechnology advancesReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The understanding of protein aggregation is a central issue in different fields of protein science, from the heterologous protein production in biotechnology to amyloid aggregation in several neurodegenerative and systemic diseases. To this goal, it became more and more evident the crucial relevance of studying protein aggregation in the complex cellular environment, since it allows to take into account the cellular components affecting protein aggregation, such as chaperones, proteases, and molecular crowding. Here, we discuss the use of several biochemical and biophysical approaches that can be employed to monitor protein aggregation within intact cells, focusing in particular on bacteria that are widely employed as microbial cell factories.
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