Trial reportAmerican journal of public health2013
The statin-iron nexus: anti-inflammatory intervention for arterial disease prevention.
Trial report in American journal of public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ferritin and transferrin predict common carotid intima-media thickness in females: a machine-learning informed individual participant data meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Ferroptosis of Macrophages and Endothelial Cells in Atherosclerosis: Molecular Mechanisms and Therapeutic Targets.Reviews in cardiovascular medicine · 2025Review
- Understanding the causes and consequences of low statin adherence: evidence from UK Biobank primary care data.BMC medicine · 2025Article
- The validity of serum ferritin levels in predicting cardiovascular events of metabolic dysfunction-associated steatotic liver disease patients may need more consideration.Hepatobiliary surgery and nutrition · 2024Article
- Possible link between statin and iron deficiency anemia: A South Korean nationwide population-based cohort study.Science advances · 2023Article
- Prevalence of anemia and associated All-Cause mortality among adults with Diabetes: The role of chronic kidney disease.Diabetes research and clinical practice · 2023Article
- Ironing out macrophages in atherosclerosis.Acta biochimica et biophysica Sinica · 2023Review
- The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Potential hazards of recent trends in liberal iron use for renal anemia.Clinical kidney journal · 2021Review
- Impact of trial design and patient heterogeneity on the identification of clinically effective therapies for progressive MS.Multiple sclerosis (Houndmills, Basingstoke, England) · 2018Article
- Iron, inflammation and atherosclerosis risk in men vs. perimenopausal women.Atherosclerosis · 2015Article
- Iron and noncontrast magnetic resonance T2* as a marker of intraplaque iron in human atherosclerosis.Journal of vascular surgery · 2015Article
- Attenuation of morphine analgesic tolerance by rosuvastatin in naïve and morphine tolerance rats.Inflammation · 2015Article
- Iron and atherosclerosis: nailing down a novel target with magnetic resonance.Journal of cardiovascular translational research · 2014Review
- Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.PloS one · 2014Article
- Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe postulated the existence of a statin-iron nexus by which statins improve cardiovascular disease outcomes at least partially by countering proinflammatory effects of excess iron stores.
methodsUsing data from a clinical trial of iron (ferritin) reduction in advanced peripheral arterial disease, the Iron and Atherosclerosis Study, we compared effects of ferritin levels versus high-density lipoprotein to low-density lipoprotein ratios (both were randomization variables) on clinical outcomes in participants receiving and not receiving statins.
resultsStatins increased high-density lipoprotein to low-density lipoprotein ratios and reduced ferritin levels by noninteracting mechanisms. Improved clinical outcomes were associated with lower ferritin levels but not with improved lipid status.
conclusionsThere are commonalities between the clinical benefits of statins and the maintenance of physiologic iron levels. Iron reduction may be a safe and low-cost alternative to statins.
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