ArticleBMC cancer2013
The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function for detecting lung cancer.
Article in BMC cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 68 citations in OpenAlex.
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- Metabolomics-based search for lung cancer markers among patients with different smoking status.Scientific reports · 2024Article
- Integration of clinical phenoms and metabolomics facilitates precision medicine for lung cancer.Cell biology and toxicology · 2024Article
- [Research Progress on Tumor Metabolic Biomarkers in Liquid Biopsy of Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Review
- Effects of methionine deficiency on B7H3-DAP12-CAR-T cells in the treatment of lung squamous cell carcinoma.Cell death & disease · 2024Article
- Causal associations of histidine and 12 site-specific cancers: a bidirectional Mendelian randomization study.Molecular genetics and genomics : MGG · 2023Article
- Review
- Systemic Metabolomic Profiles in Adult Patients with Bacterial Sepsis: Characterization of Patient Heterogeneity at the Time of Diagnosis.Biomolecules · 2023Article
- Study on plasma amino acids and piperonamide as potential diagnostic biomarkers of non-small cell lung cancer.Translational cancer research · 2022Article
- Genetically Predicted Circulating Concentrations of Alanine and Alanine Aminotransferase Were Associated with Prostate Cancer Risk.Clinical epidemiology · 2022Article
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- Metabolomic Profiling in Lung Cancer: A Systematic Review.Metabolites · 2021Review
- Tryptophan and Its Metabolites in Lung Cancer: Basic Functions and Clinical Significance.Frontiers in oncology · 2021Review
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- Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies.Metabolites · 2020Review
- Clinical significance of circulating tumor cells and metabolic signatures in lung cancer after surgical removal.Journal of translational medicine · 2020Article
- Prognostic Role of Serum Amino Acids in Head and Neck Cancer.Disease markers · 2020Article
- The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer.International journal of molecular sciences · 2019Review
- Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment.BMC cancer · 2018Article
- Biosynthetic energy cost for amino acids decreases in cancer evolution.Nature communications · 2018Article
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Authors and funding
12 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have recently reported on the changes in plasma free amino acid (PFAA) profiles in lung cancer patients and the efficacy of a PFAA-based, multivariate discrimination index for the early detection of lung cancer. In this study, we aimed to verify the usefulness and robustness of PFAA profiling for detecting lung cancer using new test samples.
methodsPlasma samples were collected from 171 lung cancer patients and 3849 controls without apparent cancer. PFAA levels were measured by high-performance liquid chromatography (HPLC)-electrospray ionization (ESI)-mass spectrometry (MS).
resultsHigh reproducibility was observed for both the change in the PFAA profiles in the lung cancer patients and the discriminating performance for lung cancer patients compared to previously reported results. Furthermore, multivariate discriminating functions obtained in previous studies clearly distinguished the lung cancer patients from the controls based on the area under the receiver-operator characteristics curve (AUC of ROC = 0.731 ~ 0.806), strongly suggesting the robustness of the methodology for clinical use. Moreover, the results suggested that the combinatorial use of this classifier and tumor markers improves the clinical performance of tumor markers.
conclusionsThese findings suggest that PFAA profiling, which involves a relatively simple plasma assay and imposes a low physical burden on subjects, has great potential for improving early detection of lung cancer.
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