ArticlePloS one2013
A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Walking the tightrope: Balancing immune checkpoints and their inhibitors in host defence against bacterial infections.Journal of applied biomedicine · 2026Review
- Dysfunctional Decidual CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- CMTM6 as a master regulator of PD-L1.Cancer immunology, immunotherapy : CII · 2022Review
- Role of the PD-1/PD-L1 Pathway in ExperimentalFrontiers in immunology · 2022Article
- Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice.Science translational medicine · 2021Article
- Inhibitory signaling sustains a distinct early memory CD8Science immunology · 2021Article
- The PD-1 Pathway Regulates Development and Function of Memory CD8Cell reports · 2020Article
- Outer Membrane Vesicles FromFrontiers in microbiology · 2020Article
- The Diverse Function of PD-1/PD-L Pathway Beyond Cancer.Frontiers in immunology · 2019Review
- Immune checkpoint blockade in infectious diseases.Nature reviews. Immunology · 2018Review
- The Outer Membrane Vesicles ofFrontiers in microbiology · 2018Article
- Functional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells.Frontiers in immunology · 2017Review
- B7-H1 antibodies lose antitumor activity due to activation of p38 MAPK that leads to apoptosis of tumor-reactive CD8Scientific reports · 2016Article
- Review
- Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment.PloS one · 2015Article
- Tissue-expressed B7-H1 critically controls intestinal inflammation.Cell reports · 2014Article
- Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells.Journal of virology · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Programmed death ligand-1 (PD-L1) is an important negative regulator of T cell immune responses via interactions with PD-1 and CD80. However, PD-L1 can also act as a positive costimulator, but the relevant counterreceptor is not known. We analyzed the role of PD-L1 in CD8-T cell responses to infection with Listeria monocytogenes (LM) or vesicular stomatitis virus (VSV). PD-L1 blockade impaired antigen-specific CD8 effector T cell expansion in response to LM, but not to VSV infection, particularly limiting short-lived effector cell differentiation. Simultaneous CD4-T cell depletion and anti-PD-L1 blockade revealed that PD-L1 provided costimulation even in the absence of CD4-T cells. Most importantly, specific blockade of PD-L1 binding to CD80 or to PD-1 did not recapitulate PDL-1 blockade. The results suggested that PD-L1 plays an important costimulatory role for antigen-specific CD8 T cells during LM infection perhaps through a distinct receptor or interaction epitope.
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Registered trials
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