ArticlePloS one2013
Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Aire-dependent interferon signalling shapes thymocyte maturation and central tolerance in mice.Communications biology · 2025Article
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- Multilevel mechanism of immune checkpoint inhibitor action in solid tumors: History, present issues and future development.Oncology letters · 2022Review
- Tumor progression mechanisms: Insights from the central immune regulation of tissue homeostasis.Oncology letters · 2019Review
- Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus.International immunology · 2019Article
- The full spectrum of human naive T cells.Nature reviews. Immunology · 2018Review
- Twenty Years of AIRE.Frontiers in immunology · 2018Review
- Critical role of SP thymocyte motility in regulation of thymic output in neonatal Aire-/- mice.Oncotarget · 2017Article
- Dynamics of Recent Thymic Emigrants in Young Adult Mice.Frontiers in immunology · 2017Article
- Thymic DCs derived IL-27 regulates the final maturation of CD4(+) SP thymocytes.Scientific reports · 2016Article
- Control of the thymic medulla and its influence on αβT-cell development.Immunological reviews · 2016Review
- Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling.Nature immunology · 2016Article
- Liver sinusoidal endothelial cells induce tolerance of autoreactive CD4+ recent thymic emigrants.Scientific reports · 2016Article
- Maturation and migration of murine CD4 single positive thymocytes and thymic emigrants.Computational and structural biotechnology journal · 2014Review
- Maturation and emigration of single-positive thymocytes.Clinical & developmental immunology · 2013Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After a tightly regulated developmental program in the thymus, "mature" single positive (SP) thymocytes leave the thymus and enter the periphery. These newly arrived recent thymic emigrants (RTEs) are phenotypically and functionally immature, and will complete a dynamic maturation in the peripheral lymphoid organs before being licensed to be resident naïve T cells. To study the early events occurring in the RTE maturation process, we identified the phenotype of CD4(+) pre-RTEs, a population of CD4(+) SP thymocytes that have acquired the thymus egress capability. Compared to peripheral naïve T cells, CD4(+) pre-RTEs displayed superior survival capability in lymphoreplete mice and faster proliferation under lymphopenic condition. The differences in Bcl2/Bim expression and/or heightened IL-7 signaling pathway may account for the pre-RTEs' better responsiveness to homeostatic signals. Qa2, the expression of which indicates the phenotypic maturation of SPs and RTEs, was found to be upregulated in CD4(+) pre-RTEs in thymic perivascular space. Migratory dendritic cells that surround this region contribute to Qa2 expression in pre-RTEs. The dendritic cell-driven Qa2 induction of CD4(+) pre-RTEs is independent of MHC class II and Aire molecules.
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