ArticlePloS one2013
Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Angiopoietin-2 as a Prognostic Biomarker of Major Adverse Cardiovascular Events and All-Cause Mortality in Chronic Kidney Disease.PloS one · 2015Trial
- Cell-Specific Roles of Angiopoietin-2 in CKD.Journal of the American Society of Nephrology : JASN · 2026Article
- Assessing Vascular Biomarkers and Their Association with Hypertension in Paediatric Chronic Kidney Disease.Sultan Qaboos University medical journal · 2025Article
- Angiopoietin-2 and Angiopoietin-like Proteins with a Prospective Role in Predicting Diabetic Nephropathy.Biomedicines · 2024Article
- Relationship between angiogenic growth factors and atherosclerosis in renal transplantation recipients: a cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2024Article
- Endothelial dysfunction as a factor leading to arterial hypertension.Pediatric nephrology (Berlin, Germany) · 2023Article
- Targeting VE-PTP phosphatase protects the kidney from diabetic injury.The Journal of experimental medicine · 2019Article
- Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study.Journal of the American Heart Association · 2019Article
- Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study.Journal of translational medicine · 2018Observational
- CD90 Identifies Adventitial Mesenchymal Progenitor Cells in Adult Human Medium- and Large-Sized Arteries.Stem cell reports · 2018Article
- The association of angiogenic factors and chronic kidney disease.BMC nephrology · 2018Article
- Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.PloS one · 2018Article
- Endothelial dysfunction during long-term follow-up in children with STEC hemolytic-uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2017Article
- Angiopoietin-2, Angiopoietin-1 and subclinical cardiovascular disease in Chronic Kidney Disease.Scientific reports · 2016Observational
- The Malaria-High Blood Pressure Hypothesis.Circulation research · 2016Review
- Vascular Growth Factors and Glomerular Disease.Annual review of physiology · 2016Review
- Reduced Microvascular Density in Omental Biopsies of Children with Chronic Kidney Disease.PloS one · 2016Article
- Urinary angiopoietin-2 is associated with albuminuria in patients with type 2 diabetes mellitus.International journal of endocrinology · 2015Article
- The Role of Angiopoietine-2 in the Diagnosis and Prognosis of Sepsis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2015Article
- HDL in children with CKD promotes endothelial dysfunction and an abnormal vascular phenotype.Journal of the American Society of Nephrology : JASN · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Cardiovascular disease (CVD) is increasingly recognised as a complication of childhood chronic kidney disease (CKD) even in the absence of diabetes and hypertension. We hypothesized that an alteration in angiopoietin-1 and -2, growth factors which regulate endothelial and vascular function could be involved. We report that the endothelial survival factor, angiopoietin-1 is low in children with pre-dialysis CKD whereas the pro-inflammatory angiopoietin-2 is elevated in children on dialysis. In dialysis patients, angiopoietin-2 positively correlated with time on dialysis, systolic blood pressure, and carotid artery intima media thickness. Elevated angiopoietin-2 levels in dialysis versus pre-dialysis CKD patients were also associated with an anti-angiogenic (high soluble VEGFR-1 and low VEGF-A) and pro-inflammatory (high urate, E-selectin, P-selectin and VCAM-1) milieu. Ang-2 was immunodetected in arterial biopsy samples whilst the expression of VEGF-A was significantly downregulated in dialysis patients. Serum urate correlated with angiopoietin-2 levels in dialysis patients and addition of uric acid was able to induce rapid release of angiopoietin-2 from cultured endothelial cells. Thus, angiopoietin-2 is a marker for cardiovascular disease in children on chronic dialysis and may act as an anti-angiogenic and pro-inflammatory effector in this context. The possibility that the release of angiopoietin-2 from endothelia is mediated by urate should be explored further.
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