ArticlePloS one2013
Anticancer and antimicrobial activities of some antioxidant-rich cameroonian medicinal plants.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 90 citations in OpenAlex.
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- Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19.Physics and chemistry of the earth (2002) · 2022Article
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- The PI3K/AKT Pathway-The Potential Key Mechanisms of Traditional Chinese Medicine for Stroke.Frontiers in medicine · 2022Review
- Comparative study amongSaudi journal of biological sciences · 2022Article
- Evaluation of the Antidiabetic Activity of Hydromethanolic Roots Extracts ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Antibacterial, antifungal and antioxidant activities of whole plant chemical constituents of Rumex abyssinicus.BMC complementary medicine and therapies · 2021Article
- African Herbal Medicines: Adverse Effects and Cytotoxic Potentials with Different Therapeutic Applications.International journal of environmental research and public health · 2021Review
- Preclinical study of the medicinal plants for the treatment of malignant melanoma.Molecular biology reports · 2020Article
- Anthelmintic A-Type Procyanidins and Further Characterization of the Phenolic Composition of a Root Extract fromMolecules (Basel, Switzerland) · 2020Article
- Discovery of Helminthosporin, an Anthraquinone Isolated fromACS omega · 2020Article
- Sources for developing new medicinal products: biochemical investigations on alcoholic extracts obtained from aerial parts of some Romanian Amaryllidaceae species.BMC complementary and alternative medicine · 2018Article
- Biochemical Activity and Hypoglycemic Effects ofBioMed research international · 2018Article
- Achillea schurii Flowers: Chemical, Antioxidant, and Antimicrobial Investigations.Molecules (Basel, Switzerland) · 2016Article
- Effect of Rumex Abyssinicus on preneoplastic lesions in dimethylhydrazine induced colon carcinogenesis in rats.BMC complementary and alternative medicine · 2015Article
- Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk. (Salicaceae).BMC complementary and alternative medicine · 2015Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional remedies have a long-standing history in Cameroon and continue to provide useful and applicable tools for treating ailments. Here, the anticancer, antimicrobial and antioxidant activities of ten antioxidant-rich Cameroonian medicinal plants and of some of their isolated compounds are evaluated.The plant extracts were prepared by maceration in organic solvents. Fractionation of plant extract was performed by column chromatography and the structures of isolated compounds (emodin, 3-geranyloxyemodin, 2-geranylemodin) were confirmed spectroscopically. The antioxidant activity (AOA) was determined using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) bleaching method, the trolox equivalent antioxidant capacity (TEAC), and the hemoglobin ascorbate peroxidase activity inhibition (HAPX) assays. The anticancer activity was evaluated against A431 squamous epidermal carcinoma, WM35 melanoma, A2780 ovary carcinoma and cisplatin-resistant A2780cis cells, using a direct colorimetric assay. The total phenolic content in the extracts was determined spectrophotometrically by the Folin-Ciocalteu method. Rumex abyssinicus showed the best AOA among the three assays employed. The AOA of emodin was significantly higher than that of 3-geranyloxyemodin and 2-geranylemodin for both TEAC and HAPX methods. The lowest IC(50) values (i.e., highest cytotoxicity) were found for the extracts of Vismia laurentii, Psorospermum febrifugum, Pentadesma butyracea and Ficus asperifolia. The Ficus asperifolia and Psorospermum febrifugum extracts are selective against A2780cis ovary cells, a cell line which is resistant to the standard anticancer drug cisplatin. Emodin is more toxic compared to the whole extract, 3-geranyloxyemodin and 2-geranylemodin. Its selectivity against the platinum-resistant A2780cis cell line is highest. All of the extracts display antimicrobial activity, in some cases comparable to that of gentamycin.
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