ArticlePloS one2013
Substance use (alcohol, areca nut and cigarette) is associated with poor prognosis of esophageal squamous cell carcinoma.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Dietary factors and risk of mortality among patients with esophageal cancer: a systematic review.BMC cancer · 2020Pooled it
- Efficacy and safety of radiotherapy plus immunochemotherapy in patients with oligometastatic esophageal cancer.Future oncology (London, England) · 2026Article
- Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes.BMC cancer · 2022Observational
- A national study of alcohol consumption patterns among population-based U.S. cancer survivors compared with cancer-free individuals.Cancer epidemiology · 2022Article
- Review
- Development and validation of a nomogram prognostic model for esophageal cancer patients with oligometastases.Scientific reports · 2020Article
- Preoperative squamous cell carcinoma antigen and albumin serum levels predict the survival of patients with stage T1-3N0M0 esophageal squamous cell carcinoma: a retrospective observational study.Journal of cardiothoracic surgery · 2020Observational
- Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort.Frontiers in oncology · 2020Article
- Interactive online consensus survival tool for esophageal squamous cell carcinoma prognosis analysis.Oncology letters · 2019Article
- Validation study of susceptibility loci for esophageal squamous cell carcinoma identified by GWAS in a Han Chinese subgroup from Eastern China.Journal of Cancer · 2019Article
- Deficiency of IL-18 Aggravates Esophageal Carcinoma Through Inhibiting IFN-γ Production by CD8Inflammation · 2018Article
- High expression of special AT-rich sequence binding protein-1 predicts esophageal squamous cell carcinoma relapse and poor prognosis.Oncology letters · 2017Article
- Article
- Association between age, substance use, and outcomes in Medicare enrollees with prostate cancer.Journal of geriatric oncology · 2016Article
- Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma.Scientific reports · 2016Article
- Alcoholic Beverage Consumption and Chronic Diseases.International journal of environmental research and public health · 2016Review
- Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil.World journal of surgical oncology · 2016Article
- Hair dye use, regular exercise, and the risk and prognosis of prostate cancer: multicenter case-control and case-only studies.BMC cancer · 2016Article
- Combined heavy smoking and drinking predicts overall but not disease-free survival after curative resection of locoregional esophageal squamous cell carcinoma.OncoTargets and therapy · 2016Article
- Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies have reported the association between lifestyle factors and prognosis of esophageal squamous cell carcinoma (ESCC) and among these, the effects of habitual areca nut chewing have never been examined. METHODOLOGY/PRINCIPAL
findingsData from 718 pathology-proven ESCC patients recruited in a multicenter hospital-based case-control study between 2000 and 2008 in Taiwan were analyzed. Clinical and lifestyle information were obtained by chart review and questionnaire survey. Death was confirmed using the National Death Index. The mean age at diagnosis was 59.8 years and 506 (70.5%) patients presented with stage III or IV diseases. The overall 1- and 5-year survival rates were 41.8% and 9.75% respectively. In addition to clinical stage, habitual alcohol drinking was found to be the strongest predictor for ESCC survival, followed by areca chewing and smoking. Compared with non-users, patients who regularly used all three substances (alcohol, areca nut, and cigarette) had 1.52 times the risk of early death (adjusted hazard ratio = 1.52, 95% CI = 1.02-2.27, p = 0.04). In addition, the more the number of substances used, the worse the prognosis of ESCC (adjusted p for trend = 0.01). CONCLUSIONS/SIGNIFICANCE: Our study found that indulgence in more substances is a significant predictor of ESCC survival. Further mechanistic studies are necessary to elucidate how these substances lead to an adverse outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.