ArticlePloS one2013
eIF4GI facilitates the MicroRNA-mediated gene silencing.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Engineered human Argonaute 2 for targeted C-to-U RNA base editing.Nature biotechnology · 2026Article
- Hepatitis virus-associated B cell non-Hodgkin's lymphoma involves dysregulated epigenetic and RNA-mediated regulatory gene expression and altered snoRNA transcription.Scientific reports · 2026Article
- Protein Translation in the Pathogenesis of Parkinson's Disease.International journal of molecular sciences · 2024Review
- Methyltransferases ofBiomolecules · 2022Article
- A cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosis.Cellular and molecular life sciences : CMLS · 2020Article
- RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection.PLoS pathogens · 2019Article
- Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice.Biology of reproduction · 2018Article
- Towards a molecular understanding of microRNA-mediated gene silencing.Nature reviews. Genetics · 2015Review
- MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation.Oncotarget · 2015Article
- NF-κB-modulated miR-130a targets TNF-α in cervical cancer cells.Journal of translational medicine · 2014Article
- A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome.Advances in bioinformatics · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are small noncoding RNAs that mediate post-transcriptional gene silencing by binding to complementary target mRNAs and recruiting the miRNA-containing ribonucleoprotein complexes to the mRNAs. However, the molecular basis of this silencing is unclear. Here, we show that human Ago2 associates with the cap-binding protein complex and this association is mediated by human eIF4GI, a scaffold protein required for the translation initiation. Using a cap photo-crosslinking method, we show that Ago2 closely associates with the cap structure. Taken together, these data suggest that eIF4GI participates in the miRNA-mediated post-transcriptional gene silencing by promoting the association of Ago2 with the cap-binding complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.