ArticlePloS one2013
Molecular mechanisms of nanosized titanium dioxide-induced pulmonary injury in mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- A novel MIR imaging approach for precise detection ofBiofilm · 2025Review
- Retraction: Molecular Mechanisms of Nanosized Titanium Dioxide-Induced Pulmonary Injury in Mice.PloS one · 2024Article
- Ingestion of titanium dioxide nanoparticles: a definite health risk for consumers and their progeny.Archives of toxicology · 2022Review
- A New Look at the Effects of Engineered ZnO and TiONanomaterials (Basel, Switzerland) · 2022Review
- New "Omics" Approaches as Tools to Explore Mechanistic Nanotoxicology.Advances in experimental medicine and biology · 2022Article
- Long-Term Exposure to Nanosized TiOInternational journal of molecular sciences · 2021Article
- Titanium Dioxide Nanoparticles Alter the Cellular Phosphoproteome in A549 Cells.Nanomaterials (Basel, Switzerland) · 2020Article
- Biological monitoring of workers exposed to engineered nanomaterials.Toxicology letters · 2018Review
- Protein profiling as early detection biomarkers for TiOEcotoxicology (London, England) · 2018Article
- Immunotoxicological impact and biodistribution assessment of bismuth selenide (BiScientific reports · 2017Article
- Review
- Comparative plasma proteomic studies of pulmonary TiO2 nanoparticle exposure in rats using liquid chromatography tandem mass spectrometry.Journal of proteomics · 2016Article
- Toxicological effect of TiO2 nanoparticle-induced myocarditis in mice.Nanoscale research letters · 2015Article
- Nanotechnology in respiratory medicine.Respiratory research · 2015Review
- Cell cycle synchronization reveals greater G2/M-phase accumulation of lung epithelial cells exposed to titanium dioxide nanoparticles.Environmental science and pollution research international · 2015Article
- Article
- Lung injury induced by TiO2 nanoparticles depends on their structural features: size, shape, crystal phases, and surface coating.International journal of molecular sciences · 2014Review
- Mechanisms of nanosized titanium dioxide-induced testicular oxidative stress and apoptosis in male mice.Particle and fibre toxicology · 2014Article
- Mechanistic characterization of titanium dioxide nanoparticle-induced toxicity using electron spin resonance.Journal of food and drug analysis · 2014Review
- Histomorphological evaluation of maternal and neonatal distal airspaces after maternal intake of nanoparticulate titanium dioxide: an experimental study in Wistar rats.Journal of molecular histology · 2014Article
Corrections and comments
- Retraction · 2024-01-11Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Concerns/Issues about Referencing/Attributions · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pulmonary damage induced by nanosized titanium dioxide (nano-TiO2) is of great concern, but the mechanism of how this damage may be incurred has yet to be elucidated. Here, we examined how multiple genes may be affected by nano-TiO2 exposure to contribute to the observed damage. The results suggest that long-term exposure to nano-TiO2 led to significant increases in inflammatory cells, and levels of lactate dehydrogenase, alkaline phosphate, and total protein, and promoted production of reactive oxygen species and peroxidation of lipid, protein and DNA in mouse lung tissue. We also observed nano-TiO2 deposition in lung tissue via light and confocal Raman microscopy, which in turn led to severe pulmonary inflammation and pneumonocytic apoptosis in mice. Specifically, microarray analysis showed significant alterations in the expression of 847 genes in the nano-TiO2-exposed lung tissues. Of 521 genes with known functions, 361 were up-regulated and 160 down-regulated, which were associated with the immune/inflammatory responses, apoptosis, oxidative stress, the cell cycle, stress responses, cell proliferation, the cytoskeleton, signal transduction, and metabolic processes. Therefore, the application of nano-TiO2 should be carried out cautiously, especially in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.