ArticleJournal of virology2013
RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Suppression of Interferon Response and Antiviral Strategies of Bunyaviruses.Tropical medicine and infectious disease · 2024Review
- Rift Valley Fever Virus Encephalitis: Viral and Host Determinants of Pathogenesis.Annual review of virology · 2024Review
- The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis.PLoS pathogens · 2024Article
- Endogenous ZAP affects Zika virus RNA interactome.RNA biology · 2024Article
- Limiting viral replication in hepatocytes alters Rift Valley fever virus disease manifestations.Journal of virology · 2023Article
- MAVS mediates a protective immune response in the brain to Rift Valley fever virus.PLoS pathogens · 2022Article
- Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination.Cell reports · 2022Article
- Arm race between Rift Valley fever virus and host.Frontiers in immunology · 2022Review
- Review
- Tra2beta-Dependent Regulation of RIO Kinase 3 Splicing During Rift Valley Fever Virus Infection Underscores the Links Between Alternative Splicing and Innate Antiviral Immunity.Frontiers in cellular and infection microbiology · 2021Article
- Article
- Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins.Virology journal · 2016Review
- Phleboviruses and the Type I Interferon Response.Viruses · 2016Review
- Preliminary Evaluation of a Bunyavirus Vector for Cancer Immunotherapy.Journal of virology · 2015Article
- RIG-I-dependent antiviral immunity is effective against an RNA virus encoding a potent suppressor of RNAi.Biochemical and biophysical research communications · 2015Article
- Association of symptoms and severity of rift valley fever with genetic polymorphisms in human innate immune pathways.PLoS neglected tropical diseases · 2015Article
- Activation of the chicken type I interferon response by infectious bronchitis coronavirus.Journal of virology · 2015Article
- Interplay between the Virus and Host in Rift Valley Fever Pathogenesis.Journal of innate immunity · 2015Article
- Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
Rift Valley fever virus (RVFV) is an emerging RNA virus with devastating economic and social consequences. Clinically, RVFV induces a gamut of symptoms ranging from febrile illness to retinitis, hepatic necrosis, hemorrhagic fever, and death. It is known that type I interferon (IFN) responses can be protective against severe pathology; however, it is unknown which innate immune receptor pathways are crucial for mounting this response. Using both in vitro assays and in vivo mucosal mouse challenge, we demonstrate here that RNA helicases are critical for IFN production by immune cells and that signaling through the helicase adaptor molecule MAVS (mitochondrial antiviral signaling) is protective against mortality and more subtle pathology during RVFV infection. In addition, we demonstrate that Toll-like-receptor-mediated signaling is not involved in IFN production, further emphasizing the importance of the RNA cellular helicases in type I IFN responses to RVFV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.