ArticleJournal of virology2013
Congruent evolution of fitness and genetic robustness in vesicular stomatitis virus.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- The evolution of robustness and fragility during long-term bacterial adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Changing fitness effects of mutations through long-term bacterial evolution.Science (New York, N.Y.) · 2024Article
- Mutational robustness changes during long-term adaptation in laboratory budding yeast populations.eLife · 2022Article
- Higher-fitness yeast genotypes are less robust to deleterious mutations.Science (New York, N.Y.) · 2019Article
- Viral Fitness Correlates with the Magnitude and Direction of the Perturbation Induced in the Host's Transcriptome: The Tobacco Etch Potyvirus-Tobacco Case Study.Molecular biology and evolution · 2018Article
- Antigenic diversification is correlated with increased thermostability in a mammalian virus.Virology · 2016Article
- The Mutational Robustness of Influenza A Virus.PLoS pathogens · 2016Article
- Evolvability and robustness in populations of RNA virus Φ6.Frontiers in microbiology · 2014Article
- Determining the cellular diversity of hepatitis C virus quasispecies by single-cell viral sequencing.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quasispecies theory is a case of mutation-selection balance for evolution at high mutation rates, such as those observed in RNA viruses. One of the main predictions of this model is the selection for robustness, defined as the ability of an organism to remain phenotypically unchanged in the face of mutation. We have used a collection of vesicular stomatitis virus strains that had been evolving either under positive selection or under random drift. We had previously shown that the former increase in fitness while the latter have overall fitness decreases (I. S. Novella, J. B. Presloid, T. Zhou, S. D. Smith-Tsurkan, B. E. Ebendick-Corpus, R. N. Dutta, K. L. Lust, and C. O. Wilke, J. Virol. 84:4960-4968, 2010). Here, we determined the robustness of these strains and demonstrated that strains under positive selection not only increase in fitness but also increase in robustness. In contrast, strains under drift not only decreased in fitness but also decreased in robustness. There was a good overall correlation between fitness and robustness. We also tested whether there was a correlation between fitness and thermostability, and we observed that the correlation was imperfect, indicating that the fitness effects of mutations are exerted in part at a level other than changing the resistance of the protein to temperature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.