ReviewWiley interdisciplinary reviews. Systems biology and medicine
Modeling cellular compartmentation in one-carbon metabolism.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Regulatory mechanisms of one-carbon metabolism enzymes.The Journal of biological chemistry · 2023Review
- Recent Advances in Drumstick (Antioxidants (Basel, Switzerland) · 2022Review
- Review
- Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines.International journal of molecular sciences · 2021Article
- Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals.Frontiers in cell and developmental biology · 2021Review
- Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.Cell metabolism · 2019Article
- The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism.Scientific reports · 2019Article
- Toward a better understanding of folate metabolism in health and disease.The Journal of experimental medicine · 2019Review
- One-Carbon Metabolism Regulates Embryonic Stem Cell Fate Through Epigenetic DNA and Histone Modifications: Implications for Transgenerational Metabolic Disorders in Adults.Frontiers in cell and developmental biology · 2019Article
- Nuclear Folate Metabolism.Annual review of nutrition · 2018Review
- Fluorescent probes for imaging formaldehyde in biological systems.Current opinion in chemical biology · 2017Review
- A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis.Scientific reports · 2017Article
- Phytochemicals of Moringa oleifera: a review of their nutritional, therapeutic and industrial significance.3 Biotech · 2016Review
- One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling.International journal of molecular sciences · 2016Review
- Article
- Relative bioavailability of folate from the traditional food plant Moringa oleifera L. as evaluated in a rat model.Journal of food science and technology · 2016Article
- The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation.Scientific reports · 2015Article
- The genomics of micronutrient requirements.Genes & nutrition · 2015Article
- Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency.The Journal of biological chemistry · 2014Article
- Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.Molecular cell · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Folate-mediated one-carbon metabolism (FOCM) is associated with risk for numerous pathological states including birth defects, cancers, and chronic diseases. Although the enzymes that constitute the biological pathways have been well described and their interdependency through the shared use of folate cofactors appreciated, the biological mechanisms underlying disease etiologies remain elusive. The FOCM network is highly sensitive to nutritional status of several B-vitamins and numerous penetrant gene variants that alter network outputs, but current computational approaches do not fully capture the dynamics and stochastic noise of the system. Combining the stochastic approach with a rule-based representation will help model the intrinsic noise displayed by FOCM, address the limited flexibility of standard simulation methods for coarse-graining the FOCM-associated biochemical processes, and manage the combinatorial complexity emerging from reactions within FOCM that would otherwise be intractable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.