ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2013
Monitoring autophagy in the treatment of protein aggregate diseases: steps toward identifying autophagic biomarkers.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Targeting Autophagy, Ferroptosis, and Neuroinflammation: Polyphenol-Mediated Modulation of Emerging Signaling Pathways in Neurodegeneration.Molecular neurobiology · 2026Review
- Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington's disease.Archives of pharmacal research · 2024Review
- Interleukin 7 inhibit autophagy via P53 regulated AMPK/mTOR signaling pathway in non-small cell lung cancer.Scientific reports · 2022Article
- New Avenues for the Treatment of Huntington's Disease.International journal of molecular sciences · 2021Review
- Inhibitory Effects of Dopamine Receptor DScientific reports · 2017Article
- Autophagy and Tubular Cell Death in the Kidney.Seminars in nephrology · 2016Review
- Autophagic cellular responses to physical exercise in skeletal muscle.Sports medicine (Auckland, N.Z.) · 2014Review
- Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction.PloS one · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Neurodegenerative diseases such as Huntington disease, Parkinson's disease, and Alzheimer's disease are caused by the accumulation of aggregate prone proteins. Pathogenic proteins misfold, aggregate, and escape the cell's normal degradative pathways. Protein aggregates subsequently lead to the toxic disruption of normal cellular processes leading, ultimately, to disease. Several lines of evidence suggest that reducing the burden of these toxic aggregates is therapeutic. One mechanism proposed to facilitate the degradation or clearance of these protein inclusions is macroautophagy. While autophagic treatment paradigms for neurodegeneration are still in the early stages of preclinical development, it is essential to identify and validate methods to measure the activation of autophagy in human patients. These methods will serve as important biomarkers necessary to test compound efficacy and monitor clinical improvement.
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Registered trials
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