ArticleMedical microbiology and immunology2013
Subneutralizing antibodies to enterovirus 71 induce antibody-dependent enhancement of infection in newborn mice.
Article in Medical microbiology and immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Enterovirus A71 priorities, challenges, and future opportunities in humoral immunity and vaccine development.NPJ vaccines · 2025Review
- Murine models of neonatal susceptibility to a clinical strain of enterovirus A71.Virus research · 2023Article
- Safety and Considerations of the COVID-19 Vaccine Massive Deployment.Virologica Sinica · 2021Article
- Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease.International journal of molecular sciences · 2019Review
- Enterovirus A71 Infection Activates Human Immune Responses and Induces Pathological Changes in Humanized Mice.Journal of virology · 2019Article
- Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy.Viruses · 2018Review
- Factors associated with fatal outcome of children with enterovirus A71 infection: a case series.Epidemiology and infection · 2018Observational
- Structure, Immunogenicity, and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid.Journal of virology · 2018Article
- Enterovirus 71 infection impairs the reproductive capacity of female mice.Experimental and therapeutic medicine · 2017Article
- Construction and characterization of infectious cDNA clones of enterovirus 71 (EV71).Virologica Sinica · 2015Article
- EV71 infection correlates with viral IgG preexisting at pharyngo-laryngeal mucosa in children.Virologica Sinica · 2015Article
- Novel recombinant chimeric virus-like particle is immunogenic and protective against both enterovirus 71 and coxsackievirus A16 in mice.Scientific reports · 2015Article
- Article
- Virus antibody dynamics in primary and secondary dengue infections.Journal of mathematical biology · 2014Article
- Recombinant tandem multi-linear neutralizing epitopes of human enterovirus 71 elicited protective immunity in mice.Virology journal · 2014Article
- Animal models of enterovirus 71 infection: applications and limitations.Journal of biomedical science · 2014Review
- Recombinant feline coronaviruses as vaccine candidates confer protection in SPF but not in conventional cats.Veterinary microbiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibody-dependent enhancement (ADE) of virus infections can be induced by subneutralizing concentrations of specific antibodies. We recently demonstrated ADE in human monocytes infected with enterovirus 71 (EV71). The current study was designed to extend these observations by determining the effect of ADE on the pathogenesis of EV71 infection in newborn mice. We compared the clinical manifestations, mortality, virus titer, histopathology, and serum levels of cytokines and chemokines in newborn mice pretreated with subneutralizing antibodies to EV71 or normal mouse IgG with and without virus. Seven-day-old ICR mice were pretreated with a wide range of mouse anti-EV71 IgG 24 h prior to intraperitoneal injection of EV71. Mice were protected from infection by neutralizing doses of anti-EV71 IgG ranging from 6.43 × 10⁻¹ to 329.6 μg/ml. Subneutralizing doses ranging from 2.01 × 10⁻² to 3.21 × 10⁻¹ μg/ml were found to significantly increase 14-day mortality compared to virus alone. The ADE effect was not evident at lower doses. Histopathological examination of mice given a subneutralizing dose of 8.04 × 10⁻² μg/ml revealed extensive neuronal and muscular damage compared to untreated infected controls. Higher serum levels of interferon (IFN)-γ and monocyte chemoattractant protein (MCP)-1 were noted in mice pretreated with subneutralizing doses than untreated infected controls. These findings support the concept that subneutralizing antibodies directed enhance EV71 induce ADE in newborn mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.