ArticleJournal of rehabilitation research and development2012
Regional cortical and trabecular bone loss after spinal cord injury.
Article in Journal of rehabilitation research and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01093014 (Novel Intervention to Influence Muscle Plasticity in Veterans), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Novel Intervention to Influence Muscle Plasticity in Veterans
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Evaluating the efficacy of functional electrical stimulation therapy assisted walking after chronic motor incomplete spinal cord injury: effects on bone biomarkers and bone strength.The journal of spinal cord medicine · 2017Trial
- Sliding and lower limb mechanics during sit-stand-sit transitions with a standing wheelchair.BioMed research international · 2014Trial
- Integration of functional electrical stimulation during robotic-assisted intervention to increase bone mineral density in individuals with complete spinal cord injury: case report.Spinal cord series and cases · 2024Article
- Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use.The journal of spinal cord medicine · 2024Article
- Article
- Characteristics Associated with Bone Loss after Spinal Cord Injury: Implications for Hip Region Vulnerability.Endocrinology and metabolism (Seoul, Korea) · 2023Article
- Impaired Glucose Tolerance and Visceral Adipose Tissue Thickness among Lean and Non-Lean People with and without Spinal Cord Injury.Journal of functional morphology and kinesiology · 2023Article
- High prevalence of low bone mineral density but normal trabecular bone score in Norwegian elite Para athletes.Frontiers in sports and active living · 2023Article
- Acute Low Force Electrically Induced Exercise Modulates Post Prandial Glycemic Markers in People with Spinal Cord Injury.Journal of functional morphology and kinesiology · 2022Article
- Time course changes to structural, mechanical and material properties of bone in rats after complete spinal cord injury.Journal of musculoskeletal & neuronal interactions · 2022Article
- Spatiotemporal responses of trabecular and cortical bone to complete spinal cord injury in skeletally mature rats.Bone reports · 2022Article
- Fibula response to disuse: a longitudinal analysis in people with spinal cord injury.Archives of osteoporosis · 2022Article
- Genomic and Epigenomic Evaluation of Electrically Induced Exercise in People With Spinal Cord Injury: Application to Precision Rehabilitation.Physical therapy · 2022Article
- Measuring tibial hemodynamics and metabolism at rest and after exercise using near-infrared spectroscopy.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2021Article
- Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research.Journal of neurotrauma · 2021Review
- Exploring changes in bone mass in individuals with a chronic spinal cord injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Observational
- Global and site-specific analysis of bone in a rat model of spinal cord injury-induced osteoporosis.Bone reports · 2020Article
- Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury.Asian spine journal · 2020Article
- Impact of short- and long-term electrically induced muscle exercise on gene signaling pathways, gene expression, and PGC1a methylation in men with spinal cord injury.Physiological genomics · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Spinal cord injury (SCI) triggers rapid loss of trabecular bone mineral density (BMD) in bone epiphyses and a loss of cortical cross-sectional area (CSA) in bone diaphyses, increasing fracture risk for people with SCI. The purpose of this study was to measure trabecular BMD and cortical CSA loss at several previously unexamined lower-limb sites (4% fibula, 12% femur, 86% tibia, cortical) in individuals with SCI. Using peripheral quantitative computed tomography, we scanned 13 participants with SCI longitudinally and 16 on one occasion; 21 participants without SCI served as controls. In the first year post-SCI, 15% to 35% of BMD was lost at the distal femur, proximal tibia, and distal fibula. Bone loss at the distal fibula accelerated between 1 and 2 years post-SCI. BMD at these sites reached a steady state value of ~50% of the non-SCI value 4 years post-SCI. At the tibia diaphysis, cortical CSA decline was slower, eventually reaching 65% of the non-SCI value. Because of the extensive loss of bone observed at these sites, careful consideration needs to be given to the dose of musculoskeletal stress delivered during rehabilitation interventions like standing, muscle electrical stimulation, and aggressive stretching of spastic muscles.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.