ArticleCerebellum (London, England)2013
TRPC3 channel underlies cerebellar long-term depression.
Article in Cerebellum (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Review
- TRPC3 Channel Activity and Viability of Purkinje Neurons can be Regulated by a Local Signalosome.Frontiers in molecular biosciences · 2022Article
- Article
- Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination.International journal of molecular sciences · 2020Article
- How TRPC Channels Modulate Hippocampal Function.International journal of molecular sciences · 2020Review
- TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.Molecular brain · 2020Article
- Disrupted Calcium Signaling in Animal Models of Human Spinocerebellar Ataxia (SCA).International journal of molecular sciences · 2019Review
- Article
- Ion channel dysfunction in cerebellar ataxia.Neuroscience letters · 2019Review
- From Mice to Men: TRPC3 in Cerebellar Ataxia.Cerebellum (London, England) · 2017Article
- The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.Cerebellum (London, England) · 2014Review
- Article
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Authors and funding
1 author at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebellar long-term depression (LTD) is induced by repetitive pairing of both synaptic inputs provided by climbing fibers (CFs) and parallel fibers (PFs), especially when CF stimulation followed by burst of PFs. Metabotropic glutamate receptor type 1 (mGluR1)-dependent signaling in Purkinje cells is critically involved in the induction of cerebellar LTD. Signaling pathway of mGluR1 has two limbs: one is IP3 receptor-mediated Ca release from intracellular Ca store and the other is activation of transient receptor potential canonical (TRPC) channels. Here, we hypothesized that TRPC3, which is reported to be responsible for mGluR1-evoked slow currents, mediates the induction of the cerebellar LTD. Purkinje cells were loaded with antibodies which act against a cytoplasmic epitope of TRPC3 channels, acting as a specific antagonist of TRPC3. About 30 min after achieving a whole-cell configuration, mGluR1-evoked slow currents were significantly reduced; a possible cause of this time delay might be the diffusion time course from patch pipette to the dendrite site of mGluR1 activation. Taking this delay into consideration, we next attempted to induce cerebellar LTD by pairing PFs and CF. It was found that cerebellar LTD was hindered in the presence of TRPC3 antibodies. Taken together, our data suggest that TRPC3 activation may be essential for the induction of LTD in cerebellar Purkinje cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.