ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Microscale inhomogeneity of brain tissue distorts electrical signal propagation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Electroconductive Nanofibrous Scaffolds Enable Neuronal Differentiation in Response to Electrical Stimulation without Exogenous Inducing Factors.Bioengineering (Basel, Switzerland) · 2023Article
- Extracellular and intracellular components of the impedance of neural tissue.Biophysical journal · 2022Article
- An Algorithm for Tracking the Position and Velocity of Multiple Neuronal Signals Using Implantable Microelectrodes In Vivo.Micromachines · 2021Article
- Conductance of porous media depends on external electric fields.Biophysical journal · 2021Article
- Intracellular Properties of Deep-Layer Pyramidal Neurons in Frontal Eye Field of Macaque Monkeys.Frontiers in synaptic neuroscience · 2021Article
- Reversible Functional Changes Evoked by Anodal Epidural Direct Current Electrical Stimulation of the Rat Auditory Cortex.Frontiers in neuroscience · 2019Article
- Is the Extracellular Impedance High and Non-resistive in Cerebral Cortex?Biophysical journal · 2017Article
- Magnitude and behavior of cross-talk effects in multichannel electrophysiology experiments.Journal of neurophysiology · 2017Article
- Low- and high-gamma oscillations deviate in opposite directions from zero-phase synchrony in the limbic corticostriatal loop.Journal of neurophysiology · 2016Article
- Intracellular Impedance Measurements Reveal Non-ohmic Properties of the Extracellular Medium around Neurons.Biophysical journal · 2016Article
- Generation of field potentials and modulation of their dynamics through volume integration of cortical activity.Journal of neurophysiology · 2015Article
- Independent components of neural activity carry information on individual populations.PloS one · 2014Article
- Revealing neuronal function through microelectrode array recordings.Frontiers in neuroscience · 2014Review
- Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
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4 authors.
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Abstract
Interpretations of local field potentials (LFPs) are typically shaped on an assumption that the brain is a homogenous conductive milieu. However, microscale inhomogeneities including cell bodies, dendritic structures, axonal fiber bundles and blood vessels are unequivocally present and have different conductivities and permittivities than brain extracellular fluid. To determine the extent to which these obstructions affect electrical signal propagation on a microscale, we delivered electrical stimuli intracellularly to individual cells while simultaneously recording the extracellular potentials at different locations in a rat brain slice. As compared with relatively unobstructed paths, signals were attenuated across frequencies when fiber bundles were in between the stimulated cell and the extracellular electrode. Across group of cell bodies, signals were attenuated at low frequencies, but facilitated at high frequencies. These results show that LFPs do not reflect a democratic representation of neuronal contributions, as certain neurons may contribute to the LFP more than others based on the local extracellular environment surrounding them.
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