ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Shift in Kiss1 cell activity requires estrogen receptor α.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 96 citations in OpenAlex.
- Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation.Reviews in endocrine & metabolic disorders · 2026Review
- Reproductive experience promotes permanent body growth independently of growth hormone.bioRxiv : the preprint server for biology · 2026Article
- GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice.Journal of neuroendocrinology · 2026Article
- Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge.Frontiers in endocrinology · 2026Article
- Neuronal plasticity at puberty in mouse hypothalamicProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative Analysis of GnRH Pulse Generator Activity in Intact and Gonadectomized Male and Female Mice.Endocrinology · 2025Article
- Article
- Activation of ionotropic and group I metabotropic glutamate receptors stimulates kisspeptin neuron activity in mice.Journal of neuroendocrinology · 2025Article
- Kiss1 receptor knockout exacerbates airway hyperresponsiveness and remodeling in a mouse model of allergic asthma.Respiratory research · 2024Article
- Article
- New methods to investigate the GnRH pulse generator.Journal of molecular endocrinology · 2024Review
- Mechanism of Arcuate Kisspeptin Neuron Synchronization in Acute Brain Slices From Female Mice.Endocrinology · 2023Article
- Hypothalamic kisspeptin neurons as potential mediators of estradiol negative and positive feedback.Peptides · 2023Review
- Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice.Nature communications · 2022Article
- Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling.Annual review of physiology · 2022Review
- ERα Signaling in GHRH/Kiss1 Dual-Phenotype Neurons Plays Sex-Specific Roles in Growth and Puberty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Postnatal Overnutrition Induces Changes in Synaptic Transmission to Leptin Receptor-Expressing Neurons in the Arcuate Nucleus of Female Mice.Nutrients · 2020Article
- Targeted Deletion of PTEN in Kisspeptin Cells Results in Brain Region- and Sex-Specific Effects on Kisspeptin Expression and Gonadotropin Release.International journal of molecular sciences · 2020Article
- Central aspects of systemic oestradiol negative- and positive-feedback on the reproductive neuroendocrine system.Journal of neuroendocrinology · 2020Review
- DissociatedFrontiers in neuroanatomy · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Reproductive function requires timely secretion of gonadotropin-releasing hormone, which is controlled by a complex excitatory/inhibitory network influenced by sex steroids. Kiss1 neurons are fundamental players in this network, but it is currently unclear whether different conditions of circulating sex steroids directly alter Kiss1 neuronal activity. Here, we show that Kiss1 neurons in the anteroventral periventricular and anterior periventricular nuclei (AVPV/PeN) of males and females exhibit a bimodal resting membrane potential (RMP) influenced by K(ATP) channels, suggesting the presence of two neuronal populations defined as type I (irregular firing patterns) and type II (quiescent). Kiss1 neurons in the arcuate nucleus (Arc) are also composed of firing and quiescent cells, but unlike AVPV/PeN neurons, the range of RMPs did not follow a bimodal distribution. Moreover, Kiss1 neuronal activity in the AVPV/PeN, but not in the Arc, is sexually dimorphic. In females, estradiol shifts the firing pattern of AVPV/PeN Kiss1 neurons and alters cell capacitance and spontaneous IPSCs amplitude of AVPV/PeN and Arc Kiss1 populations in an opposite manner. Notably, mice with selective deletion of estrogen receptor α (ERα) from Kiss1 neurons show cellular activity similar to that observed in ovariectomized females, suggesting that estradiol-induced changes in Kiss1 cellular properties require ERα. We also show that female prepubertal Kiss1 neurons are under higher inhibitory influence and all recorded AVPV/PeN Kiss1 neurons were spontaneously active. Collectively, our findings indicate that changes in cellular activity may underlie Kiss1 action in pubertal initiation and female reproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.