ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2013
Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts.Journal of visualized experiments : JoVE · 2018Article
- Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system.Drug delivery and translational research · 2018Article
- Recombinant elastin-based nanoparticles for targeted gene therapy.Gene therapy · 2017Article
- Neoatherosclerosis and Late Thrombosis After Percutaneous Coronary Intervention: Translational Cardiology and Comparative Medicine from Bench to Bedside.The Yale journal of biology and medicine · 2017Review
- Magnetizable stent-grafts enable endothelial cell capture.Journal of magnetism and magnetic materials · 2017Article
- Vascular-targeted nanocarriers: design considerations and strategies for successful treatment of atherosclerosis and other vascular diseases.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5-based Constructs.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Review
- Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- Magnetic nanoparticles and nanocomposites for remote controlled therapies.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Nanomagnetic activation as a way to control the efficacy of nucleic acid delivery.Pharmaceutical research · 2015Article
- Targeting to endothelial cells augments the protective effect of novel dual bioactive antioxidant/anti-inflammatory nanoparticles.Molecular pharmaceutics · 2014Article
- Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation.Biomaterials · 2014Article
- Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues.Nanomedicine (London, England) · 2014Article
- Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents.Angiology: open accessArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gene therapeutic strategies have shown promise in treating vascular disease. However, their translation into clinical use requires pharmaceutical carriers enabling effective, site-specific delivery as well as providing sustained transgene expression in blood vessels. While replication-deficient adenovirus (Ad) offers several important advantages as a vector for vascular gene therapy, its clinical applicability is limited by rapid inactivation, suboptimal transduction efficiency in vascular cells, and serious systemic adverse effects. We hypothesized that novel zinc oleate-based magnetic nanoparticles (MNPs) loaded with Ad would enable effective arterial cell transduction by shifting vector processing to an alternative pathway, protect Ad from inactivation by neutralizing factors, and allow site-specific gene transfer to arteries treated with stent angioplasty using a 2-source magnetic guidance strategy. Ad-loaded MNPs effectively transduced cultured endothelial and smooth muscle cells under magnetic conditions compared to controls and retained capacity for gene transfer after exposure to neutralizing antibodies and lithium iodide, a lytic agent causing disruption of free Ad. Localized arterial gene expression significantly stronger than in control animal groups was demonstrated after magnetically guided MNP delivery in a rat stenting model 2 and 9 d post-treatment, confirming feasibility of using Ad-loaded MNPs to achieve site-specific transduction in stented blood vessels. In conclusion, Ad-loaded MNPs formed by controlled precipitation of zinc oleate represent a novel delivery system, well-suited for efficient, magnetically targeted vascular gene transfer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.