Evidence map›Paper›PMID 23407467›Full record

ArticleSexually transmitted diseases2013

Incidence and correlates of Chlamydia trachomatis infection in a high-risk cohort of Kenyan women.

Linnet Masese, Jared M Baeten, Barbra A Richardson, Ruth Deya, Emmanuel Kabare, Elizabeth Bukusi, Grace John-Stewart, Walter Jaoko, R Scott McClelland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linnet MaseseDepartment of Epidemiology, University of Washington, Seattle, WA 98104-2499, USA. linnet@uw.edu
Jared M Baeten
Barbra A Richardson
Ruth Deya
Emmanuel Kabare
Elizabeth Bukusi
Grace John-Stewart
Walter Jaoko
R Scott McClelland

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
INTERNATIONAL TRAINING GRANT IN EPIDEMIOLOGYD43TW000007 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 1988 to 2012
$16.3M
Vaginal Health and the Risk of HIV-1 Acquistion in Kenyan WomenP01HD064915 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JOHN-STEWART, GRACE C. · 2009 to 2013
$8.9M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
FIC NIH HHS 5D43-TW000007FIC NIH HHS D43 TW000007NIAID NIH HHS P30 AI027757NIAID NIH HHS P30-AI-27757NICHD NIH HHS K24 HD054314NICHD NIH HHS P01 HD064915NICHD NIH HHS P01 HD64915
6 · The paper itself

Abstract

backgroundIn Africa, data on Chlamydia trachomatis infection are scarce because reliable diagnosis is costly and not widely available. Our objective was to evaluate the incidence and correlates of C. trachomatis infection among high-risk Kenyan women.

methodsWe conducted prospective cohort analyses using data from a cohort of women who reported transactional sex. C. trachomatis testing was performed using the Gen-Probe Aptima GC/CT Detection System. We used Andersen-Gill proportional hazards modeling to evaluate correlates of C. trachomatis.

resultsBetween August 2006 and December 2010, 865 women contributed 2011 person-years of observation. Sixty-four women experienced 101 episodes of C. trachomatis infection (incidence rate, 5.0/100 person-years). There was a large difference in incidence by age group: those younger than 25 years had an incidence of 27.6 per 100 person-years (95% confidence interval [CI], 16.3-46.5), those 25 to 34 years old had an incidence of 8.4 per 100 person-years (95% CI, 6.4-11.0), and those 35 years and older had an incidence of 2.6 per 100 person-years (95% CI, 1.8-3.6). In multivariate analyses, younger age (<25 and 25-34 years vs. ≥35 years; hazard ratio [HR], 8.5 [95% CI, 4.1-17.7] and 2.9 [95% CI, 1.7-5.0], respectively), depot medroxyprogesterone acetate use (HR, 1.8; 95% CI, 1.1-3.0), and recent Neisseria gonorrhoeae infection (HR, 3.3; 95% CI, 1.5-7.4) were significantly associated with increased risk of acquiring C. trachomatis infection.

conclusionsThe high incidence of C. trachomatis among younger high-risk women suggests the need for screening as an important public health intervention for this population.

Indexed as

Chlamydia InfectionsAdolescentAdultAge DistributionChlamydia trachomatisFemaleFollow-Up StudiesHealth Knowledge, Attitudes, PracticeHumansIncidenceKenyaLongitudinal StudiesMiddle AgedProportional Hazards ModelsPublic HealthRisk Factors

Identifiers

PMID23407467
PMCPMC3831875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.