ArticleThe Journal of investigative dermatology2013
TREM-1 as a potential therapeutic target in psoriasis.
Article in The Journal of investigative dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Article
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- Longitudinal multimodal characterization of radiation dermatitis in the C57BL/6J mouse model.bioRxiv : the preprint server for biology · 2025Article
- Early Neutrophil Activation in Psoriatic Skin at Relapse Following Dead Sea Climatotherapy.Experimental dermatology · 2025Article
- The balance between helper T 17 and regulatory T cells in osteoimmunology and relevant research progress on bone tissue engineering.Immunity, inflammation and disease · 2024Review
- Evaluation of serum levels of soluble triggering receptor expressed on myeloid cells-1 in patients with vitiligo using Luminex-based assay.Archives of dermatological research · 2023Article
- The biology of TREM receptors.Nature reviews. Immunology · 2023Review
- Peripheral Blood Gene Expression Profile of Infants with Atopic Dermatitis.JID innovations : skin science from molecules to population health · 2023Article
- FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers.EMBO reports · 2022Article
- Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms.International journal of environmental research and public health · 2022Article
- RNA sequencing of chronic GVHD skin lesions defines shared and unique inflammatory pathways characterizing lichen planus and morphea.Blood advances · 2022Article
- The Role of Chemokines in Psoriasis-An Overview.Medicina (Kaunas, Lithuania) · 2021Review
- Infection-provoked psoriasis: Induced or aggravated (Review).Experimental and therapeutic medicine · 2021Review
- Review
- Review-Current Concepts in Inflammatory Skin Diseases Evolved by Transcriptome Analysis: In-Depth Analysis of Atopic Dermatitis and Psoriasis.International journal of molecular sciences · 2020Review
- TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone loss.Journal of clinical medicine · 2019Article
- Specimen Collection for Translational Studies in Hidradenitis Suppurativa.Scientific reports · 2019Article
- Characterization of TCF4-mediated oncogenic role in cutaneous squamous cell carcinoma.International journal of clinical and experimental pathology · 2019Article
- TREM-1; Is It a Pivotal Target for Cardiovascular Diseases?Journal of cardiovascular development and disease · 2018Review
- Insights into gene expression profiles induced by Socs3 depletion in keratinocytes.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Our group recently described a population of antigen-presenting cells that appear to be critical in psoriasis pathogenesis, termed inflammatory myeloid dendritic cells (CD11c(+)/blood dendritic cell (DC) antigen 1(-)). Triggering receptor expressed on myeloid cells type-1 (TREM-1) signaling was a major canonical pathway in the published transcriptome of these cells. TREM-1 is a member of the Ig superfamily, active through the DAP12 signaling pathway, with an unknown ligand. Activation through TREM-1 induces inflammatory cytokines, including IL-8, MCP/CCL2, and tumor necrosis factor. We now show that TREM-1 was expressed in the skin of healthy and psoriatic patients, and there was increased soluble TREM-1 in the circulation of psoriasis patients. In psoriasis lesions, TREM-1 was colocalized with DCs, as well as CD31(+) endothelial cells. TREM-1 expression was reduced with successful narrow band UVB (NB-UVB), etanercept, and anti-IL-17 treatments. An in vitro model of peptidoglycan-activated monocytes as inflammatory myeloid DCs was developed to study TREM-1 blockade, and treatment with a TREM-1 blocking chimera decreased allogeneic T-helper type 17 cell activation, as well as IL-17 production. Furthermore, TREM-1 blockade of ex vivo psoriatic DCs in an allogeneic mixed leukocyte reaction also showed a decrease in IL-17. Together, these data suggest that the TREM-1 signaling pathway may be a previously unidentified therapeutic target to prevent the effects of inflammatory myeloid DCs in psoriasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.