ArticleJournal of neurophysiology2013
Reversed timing-dependent associative plasticity in the human brain through interhemispheric interactions.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Translational neuronal ensembles: Neuronal microcircuits in psychology, physiology, pharmacology and pathology.Frontiers in systems neuroscience · 2022Review
- Modulatory Effects of Motor State During Paired Associative Stimulation on Motor Cortex Excitability and Motor Skill Learning.Frontiers in human neuroscience · 2019Article
- Putting the "Sensory" Into Sensorimotor Control: The Role of Sensorimotor Integration in Goal-Directed Hand Movements After Stroke.Frontiers in integrative neuroscience · 2019Review
- Article
- A Preliminary Comparison of Motor Learning Across Different Non-invasive Brain Stimulation Paradigms Shows No Consistent Modulations.Frontiers in neuroscience · 2018Article
- Paired associative stimulation modulates corticomotor excitability in chronic stroke: A preliminary investigation.Restorative neurology and neuroscience · 2018Article
- Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans.Neural plasticity · 2017Article
- Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction.Frontiers in cellular neuroscience · 2014Review
- Non-invasive brain stimulation in neurorehabilitation: local and distant effects for motor recovery.Frontiers in human neuroscience · 2014Review
- Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) combined with Physical Therapy on Common Musculoskeletal Conditions: A Systematic Review and Meta-Analysis.Principles and practice of clinical research (2015)Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Spike timing-dependent plasticity (STDP) has been proposed as one of the key mechanisms underlying learning and memory. Repetitive median nerve stimulation, followed by transcranial magnetic stimulation (TMS) of the contralateral primary motor cortex (M1), defined as paired-associative stimulation (PAS), has been used as an in vivo model of STDP in humans. PAS-induced excitability changes in M1 have been repeatedly shown to be time-dependent in a STDP-like fashion, since synchronous arrival of inputs within M1 induces long-term potentiation-like effects, whereas an asynchronous arrival induces long-term depression (LTD)-like effects. Here, we show that interhemispheric inhibition of the sensorimotor network during PAS, with the peripheral stimulation over the hand ipsilateral to the motor cortex receiving TMS, results in a LTD-like effect, as opposed to the standard STDP-like effect seen for contralateral PAS. Furthermore, we could show that this reversed-associative plasticity critically depends on the timing interval between afferent and cortical stimulation. These results indicate that the outcome of associative stimulation in the human brain depends on functional network interactions (inhibition or facilitation) at a systems level and can either follow standard or reversed STDP-like mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.