ArticleThe ISME journal2013
Community-wide plasmid gene mobilization and selection.
Article in The ISME journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 131 citations in OpenAlex.
- Biofilm-forming traits enrich the plasmid diversity and functional potential in particle-attached bacteria in coastal ecosystems.Microbiology spectrum · 2026Article
- The influence of depth on the global deep-sea plasmidome.Scientific reports · 2025Article
- Characterization of the Environmental Plasmidome of the Red Sea.Microbiology spectrum · 2023Article
- Article
- Diverse functional genes harboured in extracellular vesicles from environmental and human microbiota.Journal of extracellular vesicles · 2022Article
- Precise genotyping of circular mobile elements from metagenomic data uncovers human-associated plasmids with recent common ancestors.Genome research · 2022Article
- Disentangle genus microdiversity within a complex microbial community by using a multi-distance long-read binning method: example of Candidatus Accumulibacter.Environmental microbiology · 2022Article
- Long-Range PCR Reveals the Genetic Cargo of IncP-1 Plasmids in the Complex Microbial Community of an On-Farm Biopurification System Treating Pesticide-Contaminated Wastewater.Applied and environmental microbiology · 2022Article
- Genic Selection Within Prokaryotic Pangenomes.Genome biology and evolution · 2021Review
- Assessment of the plasmidome of an extremophilic microbial community from the Diamante Lake, Argentina.Scientific reports · 2021Article
- Plasmid fitness costs are caused by specific genetic conflicts enabling resolution by compensatory mutation.PLoS biology · 2021Article
- The remediation potential for PAHs ofBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Examining horizontal gene transfer in microbial communities.Nature reviews. Microbiology · 2021Review
- A Peek into the Plasmidome of Global Sewage.mSystems · 2021Article
- PlasForest: a homology-based random forest classifier for plasmid detection in genomic datasets.BMC bioinformatics · 2021Article
- ESBL ProducingFrontiers in public health · 2021Article
- Toxic trace element resistance genes and systems identified using the shotgun metagenomics approach in an Iranian mine soil.Environmental science and pollution research international · 2021Article
- The role of mobile genetic elements in organic micropollutant degradation during biological wastewater treatment.Water research X · 2020Review
- Experimental approaches to tracking mobile genetic elements in microbial communities.FEMS microbiology reviews · 2020Review
- Modeling of shotgun sequencing of DNA plasmids using experimental and theoretical approaches.BMC bioinformatics · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmids have long been recognized as an important driver of DNA exchange and genetic innovation in prokaryotes. The success of plasmids has been attributed to their independent replication from the host's chromosome and their frequent self-transfer. It is thought that plasmids accumulate, rearrange and distribute nonessential genes, which may provide an advantage for host proliferation under selective conditions. In order to test this hypothesis independently of biases from culture selection, we study the plasmid metagenome from microbial communities in two activated sludge systems, one of which receives mostly household and the other chemical industry wastewater. We find that plasmids from activated sludge microbial communities carry among the largest proportion of unknown gene pools so far detected in metagenomic DNA, confirming their presumed role of DNA innovators. At a system level both plasmid metagenomes were dominated by functions associated with replication and transposition, and contained a wide variety of antibiotic and heavy metal resistances. Plasmid families were very different in the two metagenomes and grouped in deep-branching new families compared with known plasmid replicons. A number of abundant plasmid replicons could be completely assembled directly from the metagenome, providing insight in plasmid composition without culturing bias. Functionally, the two metagenomes strongly differed in several ways, including a greater abundance of genes for carbohydrate metabolism in the industrial and of general defense factors in the household activated sludge plasmid metagenome. This suggests that plasmids not only contribute to the adaptation of single individual prokaryotic species, but of the prokaryotic community as a whole under local selective conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.