ReviewCurrent opinion in pediatrics2013
Predictive monitoring for early detection of sepsis in neonatal ICU patients.
Review in Current opinion in pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 106 citations in OpenAlex.
- Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.Journal of neonatal-perinatal medicine · 2026Article
- Early Postoperative Intra-Abdominal Pressure and Heart Rate in Relation to Time to Trophic Enteral Feeding After Posterolateral Congenital Diaphragmatic Hernia Repair: An Exploratory Cohort Study.Children (Basel, Switzerland) · 2026Article
- Reduced heart rate variability predicts severe intraventricular haemorrhage in extremely preterm infants.Pediatric research · 2026Article
- Vital signs, demographics, and clinical events for low-birth-weight infants from four intensive care units.medRxiv : the preprint server for health sciences · 2026Article
- Decrypting network physiology for clinical practice.Frontiers in network physiology · 2026Review
- Evidence-based risk stratification for neonatal acute kidney injury: a call to action.Pediatric nephrology (Berlin, Germany) · 2025Article
- Maximum heart rate and mortality in sepsis patients: a retrospective cohort study: comment.Internal and emergency medicine · 2025Article
- CongenitalAntibiotics (Basel, Switzerland) · 2025Article
- Using heart rate variability to predict neurological outcomes in preterm infants: a scoping review.Pediatric research · 2025Article
- Mathematical model of the inflammatory response to acute and prolonged lipopolysaccharide exposure in humans.NPJ systems biology and applications · 2024Article
- Intraoperative short-term blood pressure variability and postoperative acute kidney injury: a single-center retrospective cohort study using sample entropy analysis.BMC anesthesiology · 2024Article
- Diagnosis and Management of Neonatal Bacterial Sepsis: Current Challenges and Future Perspectives.Tropical medicine and infectious disease · 2024Review
- Heart rate characteristics predict risk of mortality in preterm infants in low and high target oxygen saturation ranges.ERJ open research · 2024Article
- Insight Into Neonatal Sepsis: An Overview.Cureus · 2023Review
- Evaluation of the Hypotensive Preterm Infant: Evidence-Based Practice at the Bedside?Children (Basel, Switzerland) · 2023Review
- Pilot study shows skin-to-skin care with parents improves heart rate variability in preterm infants in the neonatal intensive care unit.Frontiers in pediatrics · 2023Article
- Beyond prediction: Off-target uses of artificial intelligence-based predictive analytics in a learning health system.Learning health systems · 2023Article
- Wearable Technologies for Pediatric Patients with Surgical Infections-More than Counting Steps?Biosensors · 2022Article
- Neonatal anemia relates to intestinal injury in preterm infants.Pediatric research · 2022Article
- Analysis of Prognostic Risk Factors of Sepsis Patients in Intensive Care Unit Based on Data Analysis.Journal of healthcare engineering · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewPredictive monitoring is an exciting new field involving analysis of physiologic data to detect abnormal patterns associated with critical illness. The first example of predictive monitoring being taken from inception (proof of concept) to reality (demonstration of improved outcomes) is the use of heart rate characteristics (HRC) monitoring to detect sepsis in infants in the neonatal ICU. The commercially available 'HeRO' monitor analyzes electrocardiogram data from existing bedside monitors for decreased HR variability and transient decelerations associated with sepsis, and converts these changes into a score (the HRC index or HeRO score). This score is the fold increase in probability that a patient will have a clinical deterioration from sepsis within 24 h. This review focuses on HRC monitoring and discusses future directions in predictive monitoring of ICU patients. RECENT
findingsIn a randomized trial of 3003 very low birthweight infants, display of the HeRO score reduced mortality more than 20%. Ongoing research aims to combine respiratory and HR analysis to optimize care of ICU patients. SUMMARY: Predictive monitoring has recently been shown to save lives. Harnessing and analyzing the vast amounts of physiologic data constantly displayed in ICU patients will lead to improved algorithms for early detection, prognosis, and therapy of critical illnesses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.