ReviewCurrent opinion in pediatrics2013
Duration of empirical antibiotic therapy for infants suspected of early-onset sepsis.
Review in Current opinion in pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Trial
- The Role of C-reactive Protein Estimation in Determining the Duration of Antibiotic Therapy in Neonatal Sepsis.Cureus · 2022Article
- A decade of neonatal sepsis caused by gram-negative bacilli-a retrospective matched cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Antibiotic prescribing practices in three neonatology units in Kigali, Rwanda. - an observational study.African health sciences · 2020Observational
- A Prospective Cohort Study of Factors Associated with Empiric Antibiotic De-escalation in Neonates Suspected with Early Onset Sepsis (EOS).Paediatric drugs · 2020Article
- Anti-microbial stewardship: antibiotic use in well-appearing term neonates born to mothers with chorioamnionitis.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Intestinal Barrier Maturation in Very Low Birthweight Infants: Relationship to Feeding and Antibiotic Exposure.The Journal of pediatrics · 2017Article
- Route of infection alters virulence of neonatal septicemia Escherichia coli clinical isolates.PloS one · 2017Article
- Antibiotic Therapy for Very Low Birth Weigh Newborns in NICU.Iranian journal of pediatrics · 2016Article
- Antimicrobial therapy in neonatal intensive care unit.Italian journal of pediatrics · 2015Review
- Bacterial meningitis in infants.Clinics in perinatology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewClinicians' adherence to the Centers for Disease Control guidelines to prevent group B Streptococcus (GBS) early-onset sepsis (EOS) has reduced GBS EOS. Although evidence-based testing and empirical antibiotic initiation are likely saving lives, clinicians have less compelling data to guide duration of empirically initiated antibiotics when cultures remain sterile and clinical signs resolve quickly. Our purpose is to review current opinions and evidence influencing clinicians' choices for duration of empirically initiated antibiotics in newborns with sterile cultures. RECENT
findingsRetrospective cohort studies indicate potential for harm with longer duration of empirical antibiotics for EOS when cultures are sterile. Cohort studies indicate timing of widely used tests used to estimate EOS risk affects their predictive value, and tests acquired 24-48 h postnatally may provide reassurance for safe discontinuation. SUMMARY: Every day clinicians caring for thousands of neonates in the United States stop antibiotics which were started empirically to treat EOS on the first postnatal day. Evidence is lacking to support a universal approach to decisions on duration of empirical antibiotics when cultures remain sterile. Reviewing predictive value relative to timing of laboratory testing can help clinicians develop locally appropriate antimicrobial duration decision-making guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.