ArticleProceedings of the National Academy of Sciences of the United States of America2013
Functional consequences of sequence variation in the pheromone biosynthetic gene pgFAR for Ostrinia moths.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 99 citations in OpenAlex.
- Fatty Acid Origin of Insect Pheromones.Advances in experimental medicine and biology · 2026Review
- The genome sequence of the European Corn Borer,Wellcome open research · 2025Article
- Genetic Coupling of Mate Recognition Systems in the Genomic Era.Cold Spring Harbor perspectives in biology · 2024Review
- Differences in rectal amino acid levels determine bacteria-originated sex pheromone specificity in two closely related flies.The ISME journal · 2023Article
- Evolutionary shifts in pheromone receptors contribute to speciation in four Helicoverpa species.Cellular and molecular life sciences : CMLS · 2023Article
- Exploring the Terminal Pathway of Sex Pheromone Biosynthesis and Metabolism in the Silkworm.Insects · 2021Article
- bric à brac controls sex pheromone choice by male European corn borer moths.Nature communications · 2021Article
- A novel terpene synthase controls differences in anti-aphrodisiac pheromone production between closely related Heliconius butterflies.PLoS biology · 2021Article
- Transcriptome Analysis ofFrontiers in endocrinology · 2021Article
- Clustering of loci controlling species differences in male chemical bouquets of sympatricEcology and evolution · 2021Article
- Pheromone Odorant Receptor Responses Reveal the Presence of a Cryptic, Redundant Sex Pheromone Component in the European Corn Borer, Ostrinia nubilalis.Journal of chemical ecology · 2020Article
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- Experimental Introgression To Evaluate the Impact of Sex Specific Traits onG3 (Bethesda, Md.) · 2019Article
- Article
- Expansion of the fatty acyl reductase gene family shaped pheromone communication in Hymenoptera.eLife · 2019Article
- Article
- Behavioural elements and sensory cues involved in sexual isolation betweenRoyal Society open science · 2018Article
- Identification of the pheromone biosynthesis genes from the sex pheromone gland transcriptome of the diamondback moth, Plutella xylostella.Scientific reports · 2017Article
- The Scent Chemistry of Heliconius Wing Androconia.Journal of chemical ecology · 2017Article
- Olfaction in a viscous environment: the "color" of sexual smells in Temora longicornis.Die Naturwissenschaften · 2017Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pheromones are central to the mating systems of a wide range of organisms, and reproductive isolation between closely related species is often achieved by subtle differences in pheromone composition. In insects and moths in particular, the use of structurally similar components in different blend ratios is usually sufficient to impede gene flow between taxa. To date, the genetic changes associated with variation and divergence in pheromone signals remain largely unknown. Using the emerging model system Ostrinia, we show the functional consequences of mutations in the protein-coding region of the pheromone biosynthetic fatty-acyl reductase gene pgFAR. Heterologous expression confirmed that pgFAR orthologs encode enzymes exhibiting different substrate specificities that are the direct consequences of extensive nonsynonymous substitutions. When taking natural ratios of pheromone precursors into account, our data reveal that pgFAR substrate preference provides a good explanation of how species-specific ratios of pheromone components are obtained among Ostrinia species. Moreover, our data indicate that positive selection may have promoted the observed accumulation of nonsynonymous amino acid substitutions. Site-directed mutagenesis experiments substantiate the idea that amino acid polymorphisms underlie subtle or drastic changes in pgFAR substrate preference. Altogether, this study identifies the reduction step as a potential source of variation in pheromone signals in the moth genus Ostrinia and suggests that selection acting on particular mutations provides a mechanism allowing pheromone reductases to evolve new functional properties that may contribute to variation in the composition of pheromone signals.
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