ArticleInflammatory bowel diseases
The overlap of functional abdominal pain in pediatric Crohn's disease.
Article in Inflammatory bowel diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Prevalence of disorders of gut-brain-interaction in pediatric patients with in-remission inflammatory bowel disease: An Italian multicenter study.Journal of pediatric gastroenterology and nutrition · 2026Article
- Symptom cluster profiles in adolescents with inflammatory bowel disease: Cross-sectional study using ImproveCareNow data.Journal of pediatric gastroenterology and nutrition · 2026Article
- Overlap of Structural Gastrointestinal Disorders in Children With Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Review
- Autonomic nervous system abnormalities in children with inflammatory bowel disease and irritable bowel syndrome: a comparative study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction.Nature reviews. Gastroenterology & hepatology · 2025Review
- Prevalence of irritable bowel syndrome and functional abdominal pain disorders in children with inflammatory bowel disease in remission.JGH open : an open access journal of gastroenterology and hepatology · 2022Review
- Appraisals of Pain in Pediatric Inflammatory Bowel Disease: A Qualitative Study With Youth, Parents, and Providers.Crohn's & colitis 360 · 2022Article
- Food protein-induced allergic proctocolitis in infants: Literature review and proposal of a management protocol.The World Allergy Organization journal · 2020Review
- Opioid Analgesics Do Not Improve Abdominal Pain or Quality of Life in Crohn's Disease.Digestive diseases and sciences · 2020Article
- Biopsychosocial Correlates of Presence and Intensity of Pain in Adolescents With Inflammatory Bowel Disease.Frontiers in pediatrics · 2020Article
- Stress Triggers Flare of Inflammatory Bowel Disease in Children and Adults.Frontiers in pediatrics · 2019Review
- Gluten and Functional Abdominal Pain Disorders in Children.Nutrients · 2018Review
- Starting Young: Trends in Opioid Therapy Among US Adolescents and Young Adults With Inflammatory Bowel Disease in the Truven MarketScan Database Between 2007 and 2015.Inflammatory bowel diseases · 2018Article
- The Management of Paediatric Functional Abdominal Pain Disorders: Latest Evidence.Paediatric drugs · 2018Review
- Maladaptive Coping and Depressive Symptoms Partially Explain the Association Between Family Stress and Pain-Related Distress in Youth With IBD.Journal of pediatric psychology · 2018Observational
- Psychological Distress and Quality of Life in Pediatric Crohn Disease: Impact of Pain and Disease State.Journal of pediatric gastroenterology and nutrition · 2017Article
- Pediatric inflammatory bowel disease and depression: treatment implications.Current opinion in pediatrics · 2014Review
- Predictors of abdominal pain in depressed pediatric inflammatory bowel disease patients.Inflammatory bowel diseases · 2014Article
- The use of non-narcotic pain medication in pediatric gastroenterology.Paediatric drugs · 2014Review
- Interventions and targets aimed at improving quality in inflammatory bowel disease ambulatory care.World journal of gastroenterology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChildren with Crohn's disease (CD) may report abdominal pain despite clinical remission, suggesting that functional abdominal pain (FAP) may be playing a role. The aim of this study was to explore the presence and impact of FAP in children with CD in remission.
methodsChildren, aged 9 to 17 years, with CD were enrolled. Demographic information, the Pediatric Crohn's Disease Activity Index, and the Children's Depression Inventory were obtained. Disease remission was defined by physician global assessment, normal laboratories findings, absence of 3 or more stools a day, nocturnal stooling, bloody diarrhea, concurrent steroid therapy, strictures, or disease flare within 6 months. FAP was defined as patients with abdominal pain and CD remission. Rates of depression (Children's Depression Inventory >9) were compared.
resultsOf 307 children, 139 reported abdominal pain. Of this group, 18 of 139 (13%) children met the criteria for FAP. Despite clinical remission, 8 of 18 patients with CD having FAP were classified with active disease by Pediatric Crohn's Disease Activity Index. These patients had a higher rate of depression than patients with CD in remission with no abdominal pain (55.6% versus 29.9%; P = 0.03), similar to patients with abdominal pain from active CD (55.6% versus 44.8%; P = 0.62).
conclusionsA proportion of children with CD in remission have FAP. These children are at significant risk of depression. Future studies are needed to determine whether depression contributes to functional pain development or if pain itself leads to depression. Especially given that functional pain may exaggerate disease activity, clinicians caring for children with CD and FAP should consider evaluating for depressive disorders before escalating therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.