ReviewGerontology2013
Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review.
Review in Gerontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Features that distinguish age-related macular degeneration from aging.Experimental eye research · 2025Review
- Gene Therapy Activates Retinal Pigment Epithelium Cell Proliferation for Age-related Macular Degeneration in a Mouse Model.Current medical science · 2023Article
- Necroptosis and Neuroinflammation in Retinal Degeneration.Frontiers in neuroscience · 2022Review
- Patient Perspectives in Geographic Atrophy (GA): Exploratory Qualitative Research to Understand the Impact of GA for Patients and Their Families.The British and Irish orthoptic journal · 2019Article
- An inducible form of Nrf2 confers enhanced protection against acute oxidative stresses in RPE cells.Experimental eye research · 2017Article
- Targeting modifiable risk factors in age-related macular degeneration in optometric practice in Sweden.Clinical optometry · 2017Article
- Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans.Journal of ophthalmology · 2016Review
- Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model.Stem cells (Dayton, Ohio) · 2015Article
- Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration.Investigative ophthalmology & visual science · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAge-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated.
objectiveTo briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD.
methodsA literature review.
resultsThe discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis.
conclusionsOxidative stress and complement dysregulation play a substantive role in the development of AMD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.