ReviewAmerican journal of rhinology & allergy2013
Antibody deficiency in chronic rhinosinusitis: epidemiology and burden of illness.
Review in American journal of rhinology & allergy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Guideline
- The Cross-Knit Between Immune Cells and Thyroid Function in Autoimmune Thyroid Disorders: What We Can Learn from Inborn Errors of Immunity.Children (Basel, Switzerland) · 2026Review
- Treatment of chronic rhinosinusitis and acute recurring rhinosinusitis with omadacycline: A case series.IDCases · 2026Article
- Primary Antibody Deficiency in Patients With Chronic Rhinosinusitis: A Call for Immunologic Evaluation Prior to Biologic Therapy.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Article
- The Upper Airway as a Treatable Trait: A United-Airway Framework for Biologic Selection in Asthma.Journal of asthma and allergy · 2026Review
- Immunodeficiency and Surgical Outcomes in Chronic Rhinosinusitis.The Laryngoscope · 2025Article
- Endoscopic sinus surgery outcomes in patients with chronic rhinosinusitis and immunoglobulin deficiencies.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023Article
- Perspectives in Therapy of Chronic Rhinosinusitis.Diagnostics (Basel, Switzerland) · 2022Review
- Effect of Topical Furosemide Efficacy on Reducing Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis.Iranian journal of otorhinolaryngology · 2022Article
- Fatal epistaxis in a case of common variable immunodeficiency: A case report and review of the literature.Clinical case reports · 2022Article
- Review
- Selective IgA Deficiency and Allergy: A Fresh Look to an Old Story.Medicina (Kaunas, Lithuania) · 2022Review
- Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition.Children (Basel, Switzerland) · 2021Review
- The Role of Mesenchymal Stem Cells in the Treatment of a Chronic Rhinosinusitis-An In Vivo Mouse Model.Microorganisms · 2021Article
- Monoclonal Antibodies and Airway Diseases.International journal of molecular sciences · 2020Review
- B Cell Disorders in Children: Part II.Current allergy and asthma reports · 2020Review
- Phenotypes in Chronic Rhinosinusitis.Current allergy and asthma reports · 2020Review
- The clinical implications of selective IgA deficiency.Journal of translational autoimmunity · 2019Review
- [Immunodeficiency in chronic rhinosinusitis : An important and often underestimated cause].HNO · 2019Article
- Aeroallergens, air pollutants, and chronic rhinitis and rhinosinusitis.World journal of otorhinolaryngology - head and neck surgery · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA subset of patients with chronic rhinosinusitis (CRS) has refractory disease. The risk factors for refractory CRS include atopy, a disrupted mucociliary transport system, medical conditions affecting the sinonasal tract mucosa, and immunodeficiency.
methodsWe review four primary immunodeficiencies reported in individuals with CRS: common variable immune deficiency (CVID), selective IgA deficiency, IgG subclass deficiency, and specific antibody deficiency. We also review treatment options for individuals with both CRS and a concomitant immune defect.
resultsThere is a high prevalence of CRS in individuals with CVID and selective IgA deficiency. While many reports describe IgG subclass deficiency in individuals with CRS, the clinical relevance of this is unclear. Specific antibody deficiency may play a more significant role in the pathogenesis of refractory CRS.
conclusionScreening for a primary immunodeficiency should be part of the diagnostic workup of refractory CRS, as its identification may allow for more effective long-term therapeutic options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.