Evidence map›Paper›PMID 23406479›Full record

Trial reportAIDS care2013

"Damaging what wasn't damaged already": psychological tension and antiretroviral adherence among HIV-infected methadone-maintained drug users.

A W Batchelder, M Brisbane, A H Litwin, S Nahvi, K M Berg, J H Arnsten

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

A W Batcheldera Division of General Internal Medicine , Albert Einstein College of Medicine and Montefiore Medical Center , Bronx , NY , USA.
M Brisbane
A H Litwin
S Nahvi
K M Berg
J H Arnsten
Albert Einstein College of Medicine · USMontefiore Medical Center · USYale University · US

Funding

Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI BERMAN, JOAN WEINBERGER · 2003 to 2013
$18.6M
Efficacy and cost of HAART DOT in methadone clinicsR01DA015302 · NIDA · YESHIVA UNIVERSITY · PI ARNSTEN, JULIA H · 2003 to 2007
$4.8M
HIV and Substance Abuse Clinical Addiction Research and Education (CARE) ProgramR25DA023021 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ARNSTEN, JULIA H. · 2007 to 2014
$2.7M
CLINICAL ADDICTION RESEARCH AND EDUCATION (CARE) PROGRAMR25DA014551 · NIDA · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ARNSTEN, JULIA H. · 2002 to 2005
$1.3M
Directly Observed Hepatitis C Treatment in Methadone ClinicsK23DA022454 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI LITWIN, ALAIN HARRIS · 2008 to 2012
$904k
Varenicline Smoking Cessation Treatment for Methadone Maintenance PatientsK23DA025736 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI NAHVI, SHADI · 2010 to 2014
$903k
Improving Measurement of Antiretroviral Adherence in Current and Former Drug UserK23DA021087 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BERG, KARINA M · 2006 to 2009
$647k
NIAID NIH HHS P30 AI051519NIDA NIH HHS K23 DA021087NIDA NIH HHS K23 DA022454NIDA NIH HHS K23 DA025736NIDA NIH HHS R01 DA015302NIDA NIH HHS R25 DA014551NIDA NIH HHS R25 DA023021NIDA NIH HHS R25 DA14551
6 · The paper itself

Abstract

Active drug use among HIV-infected persons is associated with poor adherence to highly active antiretroviral therapy (HAART) and suboptimal treatment outcomes. To understand adherence experiences among HIV-infected drug users, we conducted semistructured interviews with 15 participants in a randomized controlled trial evaluating the efficacy of directly observed HAART delivered in methadone maintenance clinics. Interviews were recorded, transcribed, and thematically analyzed. We identified negative and positive psychological themes associated with both drug use and adherence. Participants described tension between negative feelings (denial, shame, and perceived isolation) and positive feelings (acceptance, motivation, empowerment, and perceived connectedness), and they associated this tension with their own drug using and adherence behaviors. Sustained antiretroviral therapy adherence may require increased emphasis on understanding the psychological experience of HIV-infected drug users.

Indexed as

AdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveDirectly Observed TherapyEvaluation Studies as TopicFemaleHIV InfectionsHumansMaleMedication AdherenceMethadoneMiddle AgedOpiate Substitution TreatmentPower, PsychologicalShameSocial SupportAnti-Retroviral AgentsMethadone

Identifiers

PMID23406479
PMCPMC3740002
OpenAlexW2072104609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.