Evidence map›Paper›PMID 23405903›Full record

ReviewImmunological reviews2013

CD4(+) T-cell subsets and host defense in the lung.

Jay K Kolls

Open access · greenAbstract readReview
In one paragraph

Review in Immunological reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. The standardization and efficacy of fermentedOpen veterinary journal · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Spinal Cord Injury Impairs Lung Immunity in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jay K KollsChildren's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. jay.kolls@chp.edu
University of Pittsburgh · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Surrogate Biomarkers for Disease Progression in IPFP50HL084932 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, ANURADHA · 2006 to 2010
$12.2M
T-Cells and P. Carinii PneumoniaR01HL062052 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 1998 to 2017
$5.1M
Th17 Cytokines and Lung ImmunityR37HL079142 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 2010 to 2017
$3.6M
NON CD4 HOST DEFENSE AGAINST P CARINII PNEUMONIAR01HL061271 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 1999 to 2013
$3.6M
NCATS NIH HHS UL1 TR000005NHLBI NIH HHS P50 HL084932NHLBI NIH HHS P50HL084932NHLBI NIH HHS R01 HL061271NHLBI NIH HHS R01 HL062052NHLBI NIH HHS R37 HL079142NHLBI NIH HHS R37HL079142
6 · The paper itself

Abstract

CD4(+) T-helper subsets are lineages of T cells that have effector function in the lung and control critical aspects of lung immunity. Depletion of these cells experimentally or by drugs or human immunodeficiency virus (HIV) infection in humans leads to the development of opportunistic infections as well as increased rates of bacteremia with certain bacterial pneumonias. Recently, it has been proposed that CD4(+) T-cell subsets may also be excellent targets for mucosal vaccination to prevent pulmonary infections in susceptible hosts. Here, we review recent findings that increase our understanding of T-cell subsets and their effector cytokines in the context of pulmonary infection.

Indexed as

CD4-Positive T-LymphocytesCoinfectionCytokinesHIV InfectionsHumansImmunity, MucosalLungMucous MembraneOpportunistic InfectionsPneumonia, BacterialT-Lymphocyte SubsetsCytokines

Identifiers

PMID23405903
PMCPMC3576701
OpenAlexW2081297860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.