Evidence map›Paper›PMID 23405898›Full record

ReviewImmunological reviews2013

Th9 cells: differentiation and disease.

Mark H Kaplan

Open access · greenAbstract readReview
In one paragraph

Review in Immunological reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 2 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 2 syntheses or guidelines pooled it, 317 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Basophils promote innate lymphoid cell responses in inflamed skin.Journal of immunology (Baltimore, Md. : 1950) · 2014
    Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Immune responses of different hosts toEuropean respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  12. Article
  13. The immunoregulatory role of helper T cells inFrontiers in immunology · 2025
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. CD4Frontiers in immunology · 2025
    Review
  19. Article
  20. Article

99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mark H KaplanDepartment of Pediatrics, Indiana University School of Medicine, HB Wells Center for Pediatric Research, Indianapolis, IN 46202, USA. mkaplan2@iupui.edu
Indiana University – Purdue University Indianapolis · US

Funding

The role of PU.1 in T helper cell heterogeneityR01AI057459 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 2005 to 2025
$8.2M
NIAID NIH HHS AI057459NIAID NIH HHS R01 AI057459
6 · The paper itself

Abstract

CD4(+) T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the potent production of interleukin-9 (IL-9). Given the pleiotropic functions of IL-9, Th9 cells might be involved in pathogen immunity and immune-mediated disease. In this review, I focus on recent developments in understanding the signals that promote Th9 differentiation, the transcription factors that regulate IL-9 expression, and finally the potential roles for Th9 cells in immunity in vivo.

Indexed as

Cell CommunicationCell DifferentiationGene Expression RegulationGenetic PleiotropyHumansImmune System DiseasesImmunity, InnateInterleukin-9Signal TransductionT-Lymphocytes, Helper-InducerTranscription FactorsInterleukin-9Transcription Factors

Identifiers

PMID23405898
PMCPMC3982928
OpenAlexW2066740231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.