ArticleThyroid : official journal of the American Thyroid Association2013
Thyroglobulin autoantibodies: is there any added value in the detection of thyroid autoimmunity in women consulting for fertility treatment?
Article in Thyroid : official journal of the American Thyroid Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 7 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 7 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Prevalence of thyroid autoantibody positivity in women with infertility: a systematic review and meta-analysis.BMC women's health · 2024Pooled it
- The impact of thyroid autoimmunity on pregnancy outcomes in women with unexplained infertility undergoing intrauterine insemination: a retrospective single-center cohort study and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Evidence-based guideline: unexplained infertility†.Human reproduction (Oxford, England) · 2023Guideline
- Pooled it
- The Impact of Autoantibodies on IVF Treatment and Outcome: A Systematic Review.International journal of molecular sciences · 2019Pooled it
- There is no association between the presence of anti-thyroid antibodies and increased reproductive loss in pregnant women after ART: a systematic review and meta-analysis.JBRA assisted reproduction · 2017Pooled it
- Female Infertility and Serum Auto-antibodies: a Systematic Review.Clinical reviews in allergy & immunology · 2017Pooled it
- Low FT4 levels in early pregnancy are associated with higher insulin therapy need in women with gestational diabetes mellitus.European thyroid journal · 2026Article
- Association between anti-Mullerian hormone and antithyroid antibodies detectability and positivity in women assisted at a fertility clinic.JBRA assisted reproduction · 2025Article
- Article
- Higher prevalence of gestational diabetes in euthyroid women with thyroid autoimmunity who were expecting a female fetus.European thyroid journal · 2025Article
- Impact of thyroid autoimmunity on the cumulative live birth rates after IVF/ICSI treatment cycles.BMC pregnancy and childbirth · 2024Article
- The impact of gut microbiota on autoimmune thyroiditis and relationship with pregnancy outcomes: a review.Frontiers in cellular and infection microbiology · 2024Review
- Impact of thyroid hormone treatment on maternal pregnancy outcomes in women with subclinical hypothyroidism without TPOAb: a retrospective cross-sectional study.Thyroid research · 2023Article
- Cut-offs for thyroid peroxidase and thyroglobulin antibodies in early pregnancy.European thyroid journal · 2022Article
- Possible added value of thyroglobulin antibody (TgAb) testing in the evaluation of thyroidal status of subjects with overweight or obesity.Journal of endocrinological investigation · 2022Article
- Association between thyroid autoimmunity and gestational diabetes mellitus in euthyroid women.European thyroid journal · 2022Article
- Thyroid Autoimmunity in Female Infertility and Assisted Reproductive Technology Outcome.Frontiers in endocrinology · 2022Review
- Thyroid autoimmunity and its negative impact on female fertility and maternal pregnancy outcomes.Frontiers in endocrinology · 2022Review
- Positive Impact of Levothyroxine Treatment on Pregnancy Outcome in Euthyroid Women with Thyroid Autoimmunity Affected by Recurrent Miscarriage.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid autoimmunity (TAI) is frequent in infertile women, but to what extent thyroglobulin autoantibodies (Tg-Abs) contribute to TAI is unclear in the literature. The aims of the present study were to determine the prevalence of TAI in women consulting for fertility problems and to investigate the impact of isolated Tg-Abs, isolated thyroid peroxidase autoantibodies (TPO-Abs), and the presence of both autoantibody types on thyroid function. Furthermore, thyroid function was compared between women with and without TAI and between infertile and fertile women.
methodsA cross-sectional data analysis nested within an ongoing prospective cohort study was performed in order to determine the prevalence of TAI in unselected women consulting our tertiary referral center for reproductive medicine (CRM). The women underwent a determination of serum thyrotropin (TSH), free thyroxine (FT4), TPO-Abs, and Tg-Abs. The cause of infertility, age, body-mass index (BMI), and smoking habits were recorded.
resultsThe prevalence of TAI was 16% (163/992). In 8% of cases, both types of autoantibodies were present, in 5% isolated positive Tg-Abs were found, and 4% had isolated positive TPO-Abs (p=0.025 and p=0.003 respectively). The prevalence of TAI was significantly higher in infertile women as compared to that in fertile controls (19% vs. 13%; p=0.047). The median serum TSH level was significantly higher in the women with TAI and with isolated positive Tg-Abs compared to that in women without TAI (1.83 [1.44] and 1.90 [0.85] vs. 1.47 [0.94] mIU/L; p<0.001 respectively). The median FT4, age, BMI, and smoking habits were comparable between the study groups.
conclusionsThe prevalence of TAI was higher in infertile women as compared to fertile women consulting our CRM. Five percent of the women had isolated positive Tg-Abs and a significantly higher serum TSH compared to that in women without TAI.
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