ArticlePloS one2013
Attachment and invasion of Neisseria meningitidis to host cells is related to surface hydrophobicity, bacterial cell size and capsule.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Acid shock triggers virulence surge accompanied by bacterial elongation in streptococcus mutans.Scientific reports · 2026Article
- Maximizing bacterial survival: integrating sense-and-respond and bet-hedging mechanisms.Trends in microbiology · 2025Review
- Characteristics of Neisseria meningitidis isolated from patients with urogenital infection in a region of China.Annals of clinical microbiology and antimicrobials · 2025Article
- Regulation of the promoter for capsular polysaccharide synthesis inMicrobiology spectrum · 2025Article
- Mechanisms governing bacterial capsular polysaccharide attachment and chain length.Annals of the New York Academy of Sciences · 2025Review
- Comparative analysis of the interactions of different Streptococcus suis strains with monocytes, granulocytes and the complement system in porcine blood.Veterinary research · 2024Article
- Detection of Novel US Neisseria meningitidis Urethritis Clade Subtypes in Japan.Emerging infectious diseases · 2023Review
- Continuing genomic evolution of theMicrobial genomics · 2023Review
- Genetic variants linked to the phenotypic outcome of invasive disease and carriage ofMicrobial genomics · 2023Article
- Meningococcal Urethritis: Old and New.Journal of clinical microbiology · 2022Review
- Availability of polyamines affects virulence and survival of Neisseria meningitidis.Journal of microbiology (Seoul, Korea) · 2022Article
- The Host-Pathogen Interactions and Epicellular Lifestyle ofFrontiers in cellular and infection microbiology · 2022Review
- Modelling evolutionary pathways for commensalism and hypervirulence inMicrobial genomics · 2021Article
- A Narrative Review of the W, X, Y, E, and NG of Meningococcal Disease: Emerging Capsular Groups, Pathotypes, and Global Control.Microorganisms · 2021Review
- Emergence of a novel urogenital-tropic Neisseria meningitidis.Current opinion in infectious diseases · 2021Review
- Lung abscess due to Neisseria meningitidis serogroup X-unexpected virulence of a commensal resulting from putative serogroup B capsular switching.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Comparison of Pathogenicity of Invasive and Carried Meningococcal Isolates of ST-4821 Complex in China.Infection and immunity · 2019Article
- Virulence Traits of a Serogroup C Meningococcus and IsogenicInfection and immunity · 2019Article
- Large Cluster of Neisseria meningitidis Urethritis in Columbus, Ohio, 2015.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Emergence of a newProceedings of the National Academy of Sciences of the United States of America · 2017Article
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13 authors.
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Abstract
We compared exemplar strains from two hypervirulent clonal complexes, strain NMB-CDC from ST-8/11 cc and strain MC58 from ST-32/269 cc, in host cell attachment and invasion. Strain NMB-CDC attached to and invaded host cells at a significantly greater frequency than strain MC58. Type IV pili retained the primary role for initial attachment to host cells for both isolates regardless of pilin class and glycosylation pattern. In strain MC58, the serogroup B capsule was the major inhibitory determinant affecting both bacterial attachment to and invasion of host cells. Removal of terminal sialylation of lipooligosaccharide (LOS) in the presence of capsule did not influence rates of attachment or invasion for strain MC58. However, removal of either serogroup B capsule or LOS sialylation in strain NMB-CDC increased bacterial attachment to host cells to the same extent. Although the level of inhibition of attachment by capsule was different between these strains, the regulation of the capsule synthesis locus by the two-component response regulator MisR, and the level of surface capsule determined by flow cytometry were not significantly different. However, the diplococci of strain NMB-CDC were shown to have a 1.89-fold greater surface area than strain MC58 by flow cytometry. It was proposed that the increase in surface area without changing the amount of anchored glycolipid capsule in the outer membrane would result in a sparser capsule and increase surface hydrophobicity. Strain NMB-CDC was shown to be more hydrophobic than strain MC58 using hydrophobicity interaction chromatography and microbial adhesion-to-solvents assays. In conclusion, improved levels of adherence of strain NMB-CDC to cell lines was associated with increased bacterial cell surface and surface hydrophobicity. This study shows that there is diversity in bacterial cell surface area and surface hydrophobicity within N. meningitidis which influence steps in meningococcal pathogenesis.
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