ArticlePloS one2013
High number of previous Plasmodium falciparum clinical episodes increases risk of future episodes in a sub-group of individuals.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- One hundred malaria attacks since birth. A longitudinal study of African children and young adults exposed to high malaria transmission.EClinicalMedicine · 2024Article
- Joint modelling of time-to-clinical malaria and parasite count in a cohort in an endemic area.Journal of medical statistics and informatics · 2019Article
- Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission.eLife · 2018Article
- A Malaria-Resistant Phenotype with Immunological Correlates in a Tanzanian Birth Cohort Exposed to Intense Malaria Transmission.The American journal of tropical medicine and hygiene · 2017Article
- Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models.BMC medicine · 2015Article
- Dynamical malaria models reveal how immunity buffers effect of climate variability.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Integration of tumour and viral genomic characterizations in HBV-related hepatocellular carcinomas.Gut · 2015Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There exists great disparity in the number of clinical P. falciparum episodes among children of the same age and living in similar conditions. The epidemiological determinants of such disparity are unclear. We used a data-mining approach to explore a nineteen-year longitudinal malaria cohort study dataset from Senegal and identify variables associated with increased risk of malaria episodes. These were then verified using classical statistics and replicated in a second cohort. In addition to age, we identified a novel high-risk group of children in whom the history of P. falciparum clinical episodes greatly increased risk of further episodes. Age and a high number of previous falciparum clinical episodes not only play major roles in explaining the risk of P. falciparum episodes but also are risk factors for different groups of people. Combined, they explain the majority of falciparum clinical attacks. Contrary to what is widely believed, clinical immunity to P. falciparum does not de facto occur following many P. falciparum clinical episodes. There exist a sub-group of children who suffer repeated clinical episodes. In addition to posing an important challenge for population stratification during clinical trials, this sub-group disproportionally contributes to the disease burden and may necessitate specific prevention and control measures.
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