ArticlePloS one2013
Plasmodium falciparum-derived uric acid precipitates induce maturation of dendritic cells.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Article
- Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria.Nature medicine · 2025Article
- Whole Blood Dendritic Cell Cytokine Production Assay.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A low serum uric acid concentration predicts a poor prognosis in adult patients with candidemia.Open medicine (Warsaw, Poland) · 2022Article
- Article
- Dendritic Cell Responses and Function in Malaria.Frontiers in immunology · 2019Review
- Dendritic Cells and Their Multiple Roles during Malaria Infection.Journal of immunology research · 2016Review
- Solving ptychography with a convex relaxation.New journal of physics · 2015Article
- High numerical aperture Fourier ptychography: principle, implementation and characterization.Optics express · 2015Article
- A surprising role for uric acid: the inflammatory malaria response.Current rheumatology reports · 2014Review
- Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.Cell reports · 2014Article
- Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.Nature medicine · 2013Article
- Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Malaria is characterized by cyclical fevers and high levels of inflammation, and while an early inflammatory response contributes to parasite clearance, excessive and persistent inflammation can lead to severe forms of the disease. Here, we show that Plasmodium falciparum-infected erythrocytes contain uric acid precipitates in the cytoplasm of the parasitophorous vacuole, which are released when erythrocytes rupture. Uric acid precipitates are highly inflammatory molecules that are considered a danger signal for innate immunity and are the causative agent in gout. We determined that P. falciparum-derived uric acid precipitates induce maturation of human dendritic cells, increasing the expression of cell surface co-stimulatory molecules such as CD80 and CD86, while decreasing human leukocyte antigen-DR expression. In accordance with this, uric acid accounts for a significant proportion of the total stimulatory activity induced by parasite-infected erythrocytes. Moreover, the identification of uric acid precipitates in P. falciparum- and P. vivax-infected erythrocytes obtained directly from malaria patients underscores the in vivo and clinical relevance of our findings. Altogether, our data implicate uric acid precipitates as a potentially important contributor to the innate immune response to Plasmodium infection and may provide a novel target for adjunct therapies.
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