ArticlePloS one2013
TGF-β and TGF-β/Smad signaling in the interactions between Echinococcus multilocularis and its hosts.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Hexokinase-3 upregulation and histone H3K18 lactylation mediate murine liver fibrosis induced by Echinococcus multilocularis.PLoS neglected tropical diseases · 2026Article
- Investigation of multifaceted wound healing effect of exopolysaccharide (EPS) produced from probiotic strain Lactiplantibacillus plantarum GD2 as in vitro and in ovo.Scientific reports · 2025Article
- Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis.PLoS neglected tropical diseases · 2024Article
- Transcriptomic analysis of subarachnoid cysts of Taenia solium reveals mechanisms for uncontrolled proliferation and adaptations to the microenvironment.Scientific reports · 2024Article
- Characterization of the immunosuppressive environment induced by larvalInfection and immunity · 2024Article
- Reconstruction of the TGF-β signaling pathway of Fasciola gigantica.Parasitology research · 2023Review
- Comprehensive analysis of gut microbiome and host transcriptome in chickens afterFrontiers in cellular and infection microbiology · 2023Article
- Ghrelin regulating liver activity and its potential effects on liver fibrosis andFrontiers in cellular and infection microbiology · 2023Review
- Transforming growth factor-β signalling regulates protoscolex formation in theFrontiers in cellular and infection microbiology · 2023Article
- Primary Infection by E. multilocularis Induces Distinct Patterns of Cross Talk between Hepatic Natural Killer T Cells and Regulatory T Cells in Mice.Infection and immunity · 2022Article
- Proteomic profiling of hydatid fluid from pulmonary cystic echinococcosis.Parasites & vectors · 2022Article
- Structural changes and expression of hepatic fibrosis-related proteins in coculture of Echinococcus multilocularis protoscoleces and human hepatic stellate cells.Parasites & vectors · 2021Article
- CD3/TCRE Expression and Immunoregulatory Milieu Induced in a Secondary Intermediate Host by Different Phases of Hydatid Cyst.Acta parasitologica · 2021Article
- Gene expression in human liver fibrosis associated with Echinococcus granulosus sensu lato.Parasitology research · 2020Article
- Study on the association between TGF-β1 and liver fibrosis in patients with hepatic cystic echinococcosis.Experimental and therapeutic medicine · 2020Article
- miRNAs and lncRNAs inInternational journal of molecular sciences · 2020Review
- Kupffer Cells: Important Participant of Hepatic Alveolar Echinococcosis.Frontiers in cellular and infection microbiology · 2020Article
- Expansion of Host Regulatory T Cells by Secreted Products of the TapewormFrontiers in immunology · 2020Article
- Article
- Echinococcus multilocularis inoculation induces NK cell functional decrease through high expression of NKG2A in C57BL/6 mice.BMC infectious diseases · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveolar echinococcosis (AE) is characterized by the development of irreversible fibrosis and of immune tolerance towards Echinococcus multilocularis (E. multilocularis). Very little is known on the presence of transforming growth factor-β (TGF-β) and other components of TGF-β/Smad pathway in the liver, and on their possible influence on fibrosis, over the various stages of infection. Using Western Blot, qRT-PCR and immunohistochemistry, we measured the levels of TGF-β1, TGF-β receptors, and down-stream Smads activation, as well as fibrosis marker expression in both a murine AE model from day 2 to 360 post-infection (p.i.) and in AE patients. TGF-β1, its receptors, and down-stream Smads were markedly expressed in the periparasitic infiltrate and also in the hepatocytes, close to and distant from AE lesions. Fibrosis was significant at 180 days p.i. in the periparasitic infiltrate and was also present in the liver parenchyma, even distant from the lesions. Over the time course after infection TGF-β1 expression was correlated with CD4/CD8 T-cell ratio long described as a hallmark of AE severity. The time course of the various actors of the TGF-β/Smad system in the in vivo mouse model as well as down-regulation of Smad7 in liver areas close to the lesions in human cases highly suggest that TGF-β plays an important role in AE both in immune tolerance against the parasite and in liver fibrosis.
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