ArticlePloS one2013
Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Diabetes mellitus and colorectal carcinoma outcomes: a meta-analysis.International journal of colorectal disease · 2020Pooled it
- The relationship between diabetes and colorectal cancer prognosis: A meta-analysis based on the cohort studies.PloS one · 2017Pooled it
- Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2016Pooled it
- Association between body mass index and prognosis of colorectal cancer: a meta-analysis of prospective cohort studies.PloS one · 2015Pooled it
- Type II diabetes and metformin use does not affect colorectal cancer prognosis.International journal of cancer · 2025Article
- Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis.Cancer medicine · 2024Article
- The impact of metformin on survival in diabetes patients with operable colorectal cancer: A nationwide retrospective cohort study.The Journal of international medical research · 2023Article
- Diabetes is associated with high risk of severe adverse events during chemotherapy for cancer patients: A single-center study.International journal of cancer · 2023Article
- The prognostic role of fasting plasma glucose levels on survival in advanced colorectal cancer patients with type II diabetes mellitus: a retrospective cohort study.Journal of gastrointestinal oncology · 2022Article
- Diabetes and Colorectal Cancer Risk: Clinical and Therapeutic Implications.Journal of diabetes research · 2022Review
- Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study.Cancers · 2021Article
- Diabetes and Clinical Outcome in Patients With Metastatic Colorectal Cancer: CALGB 80405 (Alliance).JNCI cancer spectrum · 2020Article
- Effect of exercise on colorectal cancer prevention and treatment.World journal of gastrointestinal oncology · 2019Review
- Long term survival in 200 patients with advanced stage of colorectal carcinoma and diabetes mellitus - a single institution experience.Radiology and oncology · 2019Article
- Risk of colon cancer recurrence in relation to diabetes.Cancer causes & control : CCC · 2018Article
- Associations between physical activity and comorbidities in Korean cancer survivors.Journal of cancer survivorship : research and practice · 2018Article
- Grain Intake and Clinical Outcome in Stage III Colon Cancer: Results From CALGB 89803 (Alliance).JNCI cancer spectrum · 2018Article
- Epidemiology and biology of physical activity and cancer recurrence.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Increased mortality for colorectal cancer patients with preexisting diabetes mellitus: an updated meta-analysis.Oncotarget · 2017Article
- Diabetes-induced mechanophysiological changes in the small intestine and colon.World journal of diabetes · 2017Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundTo evaluate the impact of diabetes on outcomes in colorectal cancer patients and to examine whether this association varies by the location of tumor (colon vs. rectum). PATIENTS AND
methodsThis study includes 4,131 stage I-III colorectal cancer patients, treated between 1995 and 2007 (12.5% diabetic, 53% colon, 47% rectal) in South Korea. Cox proportional hazards modeling was used to determine the prognostic influence of DM on survival endpoints.
resultsColorectal cancer patients with DM had significantly worse disease-free survival (DFS) [hazard ratio (HR) 1.17, 95% confidence interval (CI): 1.00-1.37] compared with patients without DM. When considering colon and rectal cancer independently, DM was significantly associated with worse overall survival (OS) (HR: 1.46, 95% CI: 1.11-1.92), DFS (HR: 1.45, 95% CI: 1.15-1.84) and recurrence-free survival (RFS) (HR: 1.32, 95% CI: 0.98-1.76) in colon cancer patients. No association for OS, DFS or RFS was observed in rectal cancer patients. There was significant interaction of location of tumor (colon vs. rectal cancer) with DM on OS (P = 0.009) and DFS (P = 0.007).
conclusionsThis study suggests that DM negatively impacts survival outcomes of patients with colon cancer but not rectal cancer.
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