ArticlePloS one2013
Molecular evidence for the presence of Rickettsia Felis in the feces of wild-living African apes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Retraction: Molecular Evidence for the Presence of Rickettsia Felis in the Feces of Wild-living African Apes.PloS one · 2024Article
- Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) againstFrontiers in veterinary science · 2024Article
- Aetiologies of bacterial tick-borne febrile illnesses in humans in Africa: diagnostic limitations and the need for improvement.Frontiers in medicine · 2024Review
- Survey of ticks and tick-borne pathogens in wild chimpanzee habitat in Western Uganda.Parasites & vectors · 2023Article
- A Review of Non-Invasive Sampling in Wildlife Disease and Health Research: What's New?Animals : an open access journal from MDPI · 2022Review
- Expression of Concern: Molecular Evidence for the Presence of Rickettsia Felis in the Feces of Wild-living African Apes.PloS one · 2022Article
- Molecular identification and prevalence of tick-borne pathogens in zebu and taurine cattle in North Cameroon.Parasites & vectors · 2019Article
- Studies of nonhuman primates: key sources of data on zoonoses and microbiota.New microbes and new infections · 2018Article
- Rickettsia felis: A Review of Transmission Mechanisms of an Emerging Pathogen.Tropical medicine and infectious disease · 2017Review
- Flea-Borne Rickettsioses and Rickettsiae.The American journal of tropical medicine and hygiene · 2017Review
- Detection of Bartonella tamiae, Coxiella burnetii and rickettsiae in arthropods and tissues from wild and domestic animals in northeastern Algeria.Parasites & vectors · 2016Article
- Possible Role of Rickettsia felis in Acute Febrile Illness among Children in Gabon.Emerging infectious diseases · 2015Article
- The detection of vector-borne-disease-related DNA in human stool paves the way to large epidemiological studies.European journal of epidemiology · 2015Article
- Wild gorillas as a potential reservoir of Leishmania major.The Journal of infectious diseases · 2015Article
- First report of Rickettsia felis in China.BMC infectious diseases · 2014Article
- Gorilla gorilla gorilla gut: a potential reservoir of pathogenic bacteria as revealed using culturomics and molecular tools.Scientific reports · 2014Article
- Detection of Rickettsia felis, Rickettsia typhi, Bartonella Species and Yersinia pestis in Fleas (Siphonaptera) from Africa.PLoS neglected tropical diseases · 2014Article
- Detection of termites and other insects consumed by African great apes using molecular fecal analysis.Scientific reports · 2014Article
- Article
- Common epidemiology of Rickettsia felis infection and malaria, Africa.Emerging infectious diseases · 2013Article
Corrections and comments
- Retraction · 2024-10-14Concerns/Issues about Animal Welfare · Investigation by Company/Institution · Investigation by Journal/Publisher · Lack of IRB/IACUC Approval and/or Compliance · Objections by Author(s) · Upgrade/Update of Prior Notice(s) ·
- Expression of concern · 2022-12-13Concerns/Issues about Animal Welfare · Investigation by Journal/Publisher · Updated to Retraction ·
- Expression of concern
- Retracted
Authors and funding
13 authors.
Funding
Abstract
backgroundRickettsia felis is a common emerging pathogen detected in mosquitoes in sub-Saharan Africa. We hypothesized that, as with malaria, great apes may be exposed to the infectious bite of infected mosquitoes and release R. felis DNA in their feces.
methodsWe conducted a study of 17 forest sites in Central Africa, testing 1,028 fecal samples from 313 chimpanzees, 430 gorillas and 285 bonobos. The presence of rickettsial DNA was investigated by specific quantitative real-time PCR. Positive results were confirmed by a second PCR using primers and a probe targeting a specific gene for R. felis. All positive samples were sequenced.
resultsOverall, 113 samples (11%) were positive for the Rickettsia-specific gltA gene, including 25 (22%) that were positive for R. felis. The citrate synthase (gltA) sequence and outer membrane protein A (ompA) sequence analysis indicated 99% identity at the nucleotide level to R. felis. The 88 other samples (78%) were negative using R. felis-specific qPCR and were compatible with R. felis-like organisms.
conclusionFor the first time, we detected R. felis in wild-living ape feces. This non invasive detection of human pathogens in endangered species opens up new possibilities in the molecular epidemiology and evolutionary analysis of infectious diseases, beside HIV and malaria.
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Registered trials
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