ArticleThe Plant cell2013
GLUCAN SYNTHASE-LIKE8 and STEROL METHYLTRANSFERASE2 are required for ploidy consistency of the sexual reproduction system in Arabidopsis.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 48 citations in OpenAlex.
- In situ architecture of plasmodesmata in Physcomitrium patens resolved by cryo-electron tomography.Nature plants · 2026Article
- Genome-Wide Analysis of Callose Synthase (CALS) Genes in Cabbage (International journal of molecular sciences · 2025Article
- Localization ofPlant signaling & behavior · 2023Article
- Role of GSL8 in low calcium tolerance inPlant biotechnology (Tokyo, Japan) · 2022Article
- Leaf vein patterning is regulated by the aperture of plasmodesmata intercellular channels.PLoS biology · 2022Article
- Biosynthesis and the Roles of Plant Sterols in Development and Stress Responses.International journal of molecular sciences · 2022Review
- The Fungal Effector Mlp37347 Alters Plasmodesmata Fluxes and Enhances Susceptibility to Pathogen.Microorganisms · 2021Article
- An Arabidopsis AT-hook motif nuclear protein mediates somatic embryogenesis and coinciding genome duplication.Nature communications · 2021Article
- Heritability of meiotic restitution and fertility restoration in haploid triticale.Plant cell reports · 2019Article
- Analysis of a novel mutant allele of GSL8 reveals its key roles in cytokinesis and symplastic trafficking in Arabidopsis.BMC plant biology · 2018Article
- The zinc finger protein DCM1 is required for male meiotic cytokinesis by preserving callose in rice.PLoS genetics · 2018Article
- Establishing the cell biology of apomictic reproduction in diploid Boechera stricta (Brassicaceae).Annals of botany · 2018Article
- MutS-Homolog2 silencing generates tetraploid meiocytes in tomato (Plant direct · 2018Article
- Isolation of mutants with abnormal petal epidermal cell morphology.Plant signaling & behavior · 2017Article
- A Plastid-Localized Pentatricopeptide Repeat Protein is Required for Both Pollen Development and Plant Growth in Rice.Scientific reports · 2017Article
- Spontaneous polyploidization in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Lipid Raft, Regulator of Plasmodesmal Callose Homeostasis.Plants (Basel, Switzerland) · 2017Review
- CENH3-GFP: a visual marker for gametophytic and somatic ploidy determination in Arabidopsis thaliana.BMC plant biology · 2016Article
- Callose synthesis during reproductive development in monocotyledonous and dicotyledonous plants.Plant signaling & behavior · 2016Review
- Meiosis, unreduced gametes, and parthenogenesis: implications for engineering clonal seed formation in crops.Plant reproduction · 2015Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In sexually reproducing plants, the meiocyte-producing archesporal cell lineage is maintained at the diploid state to consolidate the formation of haploid gametes. In search of molecular factors that regulate this ploidy consistency, we isolated an Arabidopsis thaliana mutant, called enlarged tetrad2 (et2), which produces tetraploid meiocytes through the stochastic occurrence of premeiotic endomitosis. Endomitotic polyploidization events were induced by alterations in cell wall formation, and similar cytokinetic defects were sporadically observed in other tissues, including cotyledons and leaves. ET2 encodes GLUCAN SYNTHASE-LIKE8 (GSL8), a callose synthase that mediates the deposition of callose at developing cell plates, root hairs, and plasmodesmata. Unlike other gsl8 mutants, in which defects in cell plate formation are seedling lethal, cytokinetic defects in et2 predominantly occur in flowers and have little effect on vegetative growth and development. Similarly, mutations in STEROL METHYLTRANSFERASE2 (SMT2), a major sterol biosynthesis enzyme, also lead to weak cytokinetic defects, primarily in the flowers. In addition, SMT2 allelic mutants also generate tetraploid meiocytes through the ectopic induction of premeiotic endomitosis. These observations demonstrate that appropriate callose and sterol biosynthesis are required for maintaining the ploidy level of the premeiotic germ lineage and that subtle defects in cytokinesis may lead to diploid gametes and polyploid offspring.
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